Sequence MD

SequenceMD provides medical genetics services within community health systems to adults and families with rare conditions, unique, or unmet medical needs

05/11/2026

Did you know up to 40% of adult epilepsy cases may have a genetic cause? For people whose seizures are hard to control, a genetic diagnosis can change everything — from which medications work best to whether a specialized diet or clinical trial could help.

If epilepsy runs in your family, started early or hasn't responded well to treatment, it may be time to ask about a genetic evaluation.

Read our latest blog to learn what that process looks like: https://sequencemd.com/adult-genetic-epilepsy-the-value-of-a-diagnosis/

04/06/2026

Muscle weakness is common. But when it follows certain patterns — affecting both sides of the body symmetrically, progressing slowly over years, appearing before age 50 without a clear cause — it may have a genetic origin.

In our latest blog post, we break down how neurogenetic conditions affect different parts of the nervous system and muscle, what red flags to look for and why early whole genome sequencing can shorten the diagnostic odyssey dramatically for patients who've been searching for answers.

If you’re a clinician seeing patients with unexplained weakness or a patient who’s been told “we just don't know,” this is worth a read: https://sequencemd.com/when-muscle-weakness-has-a-neurogenetic-cause/

03/30/2026

Happy National Doctors’ Day to the physicians who never stop asking why.

To the primary care doctors who trust their instincts when something doesn’t add up. To the neurologists, cardiologists and oncologists who push further when answers are elusive. To every physician who sits with a family navigating the unknown and refuses to give up.

At SequenceMD, we have the privilege of working with you every day — partnering to unravel unresolved symptoms, undiagnosed conditions, and complex genetic and metabolic diagnoses for patients of all ages.

Your dedication is what drives better outcomes. Today, we thank you for the work that changes everything for families searching for answers.

03/16/2026

Polygenic Risk Scoring (PRS) looks at hundreds to thousands of genetic variants to help predict your susceptibility to complex diseases like cardiovascular disease, Alzheimer’s and certain cancers. Unlike single-gene testing, PRS paints a broader picture of risk that exists from the moment you’re born. But here’s the key: genetic risk is just one layer. Family history, lifestyle and clinical data all shape your overall picture — and that’s exactly how we use it at SequenceMD.

Knowing your risk early means you can act early. Read our latest blog post to learn how PRS works, what it can (and can’t) tell you and how it fits into a complete prevention plan: https://sequencemd.com/polygenic-risk-scoring-learn-about-your-disease-risk/

03/06/2026

Understanding your genetics changes everything. SequenceMD evaluation and counseling services turn that knowledge into action — with early diagnosis, proactive health management and precision care across a full range of specialties:

• Hereditary Cancer Risks
• Cardiogenetics
• Disease Risk
• Ehlers-Danlos Syndrome (EDS)
• Family Planning
• Intellectual & Developmental Disabilities (IDD)
• Nephrogenetics
• Neurogenetics
• Pediatric Genetics

Learn more at sequencemd.com

-DanlosSyndrome

02/28/2026

Every year on Rare Disease Day (that's today!), we’re reminded that behind every rare condition is a person still searching for answers. For so many families, the road to a diagnosis is long ... years of appointments, second opinions and hearing “we’re not sure.” It can mean knowing something isn’t right — but not having the language or validation to explain or deal with it. That’s why this day matters. And that’s why we stand up.

Standing up for the undiagnosed is about more than awareness. It’s about listening when patients speak up. It’s about encouraging loved ones to keep asking questions. It’s about advocating for testing, expertise and deeper answers when “wait and see” just isn’t enough.

At SequenceMD, we work alongside patients, families and providers to help uncover those answers through comprehensive genetic evaluations and personalized support. Because getting a diagnosis can change everything — it can open doors to targeted care, connect families to resources and finally replace uncertainty with understanding. Learn about moving past misdiagnosis here: https://sequencemd.com/moving-past-misdiagnosis-the-value-of-a-genetic-evaluation/

If you’re still searching, don’t give up. Your story matters. Your questions matter. And you deserve answers.
This Rare Disease Day, let’s stand up — together — for the undiagnosed.

02/27/2026

The zebra is the symbol of rare disease patients. Traditionally, doctors are taught when they “hear hoofbeats,” expect a horse, not a zebra. But in the rare disease community, one in 10 Americans is a zebra. And Rare Disease Day (Feb. 28) is all about shining a spotlight on them.

At SequenceMD, we’re committed to finding and supporting the zebras. Through comprehensive genetic evaluations and counseling, we help families gain diagnostic clarity, uncover answers and improve outcomes. Read more about pediatric genetics here: https://sequencemd.com/pediatric-genetics/

02/26/2026

This Rare Disease Day on February 28, stand with the rare disease community. Whether you’re a patient, parent or provider, advocating for genetic answers can lead to better care and stronger support networks.

At SequenceMD, we help families pursue diagnosis clarity through comprehensive genetic evaluations and personalized counseling. Because when you have answers, you can make informed decisions, access the right specialists and plan for the future with confidence. Your voice matters. And so do answers. Read about the four areas where genetics matters most in primary care: https://sequencemd.com/4-areas-where-genetics-matters-most-in-primary-care/

02/25/2026

A diagnosis can change everything — care plans, ongoing monitoring, family planning decisions, and access to the right specialists and support networks. Rare Disease Day (February 28) is a global initiative to raise awareness and generate support for everyone who’s on a rare medical journey.

At SequenceMD, we believe clarity is powerful. Through comprehensive genetic evaluations and personalized counseling, we help patients and families understand what a diagnosis means — and what to do next. From testing to long-term care coordination, our team walks with you every step of the way. Because the right answers don’t just explain the past ... they help shape a stronger, more informed future. Learn more about ”Moving Past Misdiagnosis: The Value of a Genetic Evaluation” at https://sequencemd.com/moving-past-misdiagnosis-the-value-of-a-genetic-evaluation/.

02/24/2026

Rare Disease Day (Feb. 28) is about more than awareness — it’s about action. According to the National Organization for Rare Disorders, there are more than 10,000 known rare diseases, yet fewer than 5% have an approved treatment. And on average, it can take five or more years to receive a diagnosis. That’s a long time to live without answers.
Learn more: https://rarediseases.org/understanding-rare-disease/rare-disease-facts-and-statistics/

If you or a family member has unexplained or unresolved health issues, a genetic evaluation may help connect the dots and open doors to more targeted care, resources and support. At SequenceMD, we help families move from uncertainty to diagnosis clarity through comprehensive testing and expert genetic counseling. Read our article, “From Diagnosis to Treatment: 7 Benefits of Genetic Testing for Adults,” to see how genetic insights can reduce the financial and medical burden of undiagnosed disease, and help guide safer, more effective care:
https://sequencemd.com/from-diagnosis-to-treatment-7-benefits-of-genetic-testing-for-adults/

02/23/2026

For many families, the hardest part of a rare disease journey is the not knowing. At SequenceMD, we help uncover genetic answers — bringing clarity to prognosis, management and next steps, so uncertainty can become understanding.

This Saturday, February 28, is Rare Disease Day. According to the National Organization for Rare Disorders, 1 in 10 Americans is living with a rare disease — and more than 300 million people are affected worldwide. Too often, individuals and families are left feeling isolated and without answers. Rare Disease Day is a global movement to raise awareness and build support for everyone navigating a rare diagnosis. Learn more: https://rarediseases.org/rare-disease-day/

Wondering if genetics could provide answers for you or your family? Read our article, “10 Red Flags You May Have a Genetic Disease,” to see if testing and counseling may help: https://tinyurl.com/3ayh6tec

Address

1601 E 19th Avenue STE 6450
Denver, CO
80218

Telephone

+13038327109

Website

http://sequencemd.com/

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