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Solutions 4 Health, Devon, PA (2025)

07/25/2025

Did you know that Solutions 4 Health carries Pure Encapsulations products?

Its true! You can find all your favorite products at the same discounted prices you’ve come to expect along side our elite service 🏆

Free shipping is available on online orders over $29.

📦 Order today at https://solutions4health.com/collections/pure-encapsulations

or send us a message for personalized guidance!

07/24/2025

Frequent headaches? Fatigue? Cramping? Even though you drink plenty of water? It might not be how much you are drinking but what is missing from your water! 💧

Your body needs electrolytes to stay alive; minerals such as sodium, potassium, magnesium, chloride, and calcium.

Without them, water cannot rehydrate you properly. Hydrate smarter by following these tips:

- eat mineral rich foods 🥬
- add electrolytes to your water 🧂
- drinking consistently, listening to your thirst and energy levels ⚡️

If you want personalized guidance text/call Chris @ 610-291-8152 or Contact Us here: https://solutions4health.com/pages/contact-us-1

07/21/2025

Here is a comprehensive functional medicine protocol for a female with stress/anxiety who wants to improve cognitive health, using:

Designs for Health (DFH)

Pure Encapsulations (PE)

Nourish & Flourish (polyphenol-rich shake)

Plus targeted diet, exercise, and lifestyle support

🎯 Functional Medicine Goals
Reduce cortisol and HPA axis dysregulation

Improve cognitive performance: focus, memory, processing speed

Enhance neurotransmitter balance (GABA, serotonin, dopamine)

Support mitochondrial and brain cell function

Improve vagal tone and resilience to stress

🥗 DIET STRATEGY
✅ Emphasize:
Polyphenol-rich foods: blueberries, pomegranate, turmeric, green tea

Omega-3–rich foods: wild salmon, sardines, flaxseeds, walnuts

Magnesium and B-vitamin–rich foods: spinach, pumpkin seeds, lentils

High-protein intake (1.0–1.2 g/kg/day) for neurotransmitter building blocks

Fermented foods: kefir, sauerkraut, miso (support the gut–brain axis)

❌ Avoid:
Excess caffeine (stimulates cortisol), alcohol, and refined sugar

Ultra-processed or inflammatory foods (which impair gut-brain health)

🥤 Nourish & Flourish Shake
1x/day, ideally in the morning or early afternoon

Add: chia or flaxseeds, cinnamon, almond butter, berries, unsweetened almond milk

💊 SUPPLEMENT PROTOCOL
🔹 Stress & Anxiety Modulation
Supplement Brand Dose Purpose
NeuroCalm™ DFH 2 caps/day L-theanine, taurine, GABA support for calm focus
Adrenotone™ DFH 2 caps/day (AM) Adaptogenic blend to modulate HPA axis and cortisol
Magnesium Glycinate or NeuroMag DFH 200–300 mg PM Calms nervous system, supports sleep, GABA, and cognition

🔹 Cognitive & Neurotransmitter Support
Supplement Brand Dose Purpose
Brain Vitale™ DFH 2 caps/day Acetyl-L-carnitine, phosphatidylserine, GPC – brain energy and memory
CogniFlex™ (or CogniMag) DFH 1–2 caps/day Supports neuroplasticity and focus via L-tyrosine, Ginkgo, bacopa
OmegaAvail Ultra DFH 2–3 softgels/day EPA/DHA for anti-inflammatory and cognitive protection
SeroSyn or Mood Systems Balance PE or DFH 1 cap 2x/day Balances serotonin, dopamine (helpful for anxious rumination)

🧘‍♀️ LIFESTYLE & EXERCISE STRATEGY
Activity Goal
Daily aerobic exercise – 30–45 min Lowers cortisol, improves BDNF and blood flow to brain
Strength training – 2–3x/week Improves resilience, metabolic balance
Mindfulness meditation – 10 min/day Increases vagal tone and GABA levels
Nature exposure / grounding Calms limbic system and improves sleep and cognition
Sleep hygiene (9:30–10:30 PM bedtime) Essential for glymphatic brain detox and neurorepair

🧪 LABS TO MONITOR
Salivary cortisol (4-point) – HPA axis evaluation

DHEA-S, estradiol/progesterone (if perimenopausal)

Thyroid panel: TSH, Free T3, Free T4, Reverse T3

Vitamin D, B12 (methylcobalamin), homocysteine

Omega-3 index

CRP, IL-6 (if inflammatory symptoms present)

🧾 SAMPLE DAILY ROUTINE
Morning

Wake, sunlight exposure

Nourish & Flourish shake + Omega-3 + Adrenotone + Brain Vitale

Light movement or walk

Optional: NeuroCalm (if anxiety-prone early in the day)

Afternoon

Healthy lunch: salmon salad with EVOO, pumpkin seeds, greens

CogniFlex + water

10 min walk or breathwork break

Evening

Light dinner with vegetables and protein

Magnesium (NeuroMag or glycinate) + SeroSyn

Wind down with mindfulness or yoga nidra

07/21/2025

Here is a functional medicine protocol for a middle-aged female with hair loss, using:

Designs for Health (DFH)

Pure Encapsulations (PE)

Nourish & Flourish (polyphenol-rich shake)

Progesterone treatment support

Integrated diet, exercise, and hormonal balance

🎯 Functional Medicine Goals
Identify root causes of hair loss: hormonal, nutrient, stress, thyroid, or autoimmune

Support hair follicle health and reduce miniaturization

Correct nutrient deficiencies (especially iron, zinc, biotin, and protein)

Balance estrogen and progesterone (especially in perimenopause)

Address insulin resistance and inflammation

🔬 COMMON CAUSES TO SCREEN FOR
Low progesterone / estrogen dominance

Thyroid dysfunction (TSH, Free T3, Free T4, TPO antibodies)

Ferritin

07/21/2025

Here is a comprehensive functional medicine protocol for a male aiming to prevent arterial plaque build-up and optimize cardiovascular health, while currently taking a statin, using:

Designs for Health (DFH)

Pure Encapsulations (PE)

Nourish & Flourish (polyphenol-rich shake)

Targeted diet, exercise, and lifestyle strategies

🎯 Functional Medicine Goals
Prevent endothelial damage and atherosclerosis progression

Lower oxidized LDL and ApoB particle count

Support nitric oxide production and vascular flexibility

Counter statin-induced nutrient depletion

Reduce inflammation and promote healthy lipid metabolism

🥗 DIET STRATEGY
✅ Emphasize:
Mediterranean–DASH hybrid diet:

Cold-pressed olive oil, avocado, nuts, wild-caught salmon

Polyphenol-rich produce: berries, pomegranate, beets, arugula, leafy greens

Fermented foods: sauerkraut, kefir, kimchi

Plant-based fiber: flax, chia, lentils, oats

❌ Avoid:
Refined carbs, added sugars, seed oils (corn, canola, soybean)

Processed meats and trans fats

Excessive alcohol and ultra-processed snacks

🥤 Nourish & Flourish Shake
1x/day to support antioxidant status, nitric oxide, lipid balance

Add-ins: ground flaxseed, beet powder, cinnamon, unsweetened almond milk

💊 SUPPLEMENT PROTOCOL
🔹 Core Cardiovascular Protection
Supplement Brand Dose Purpose
Carditone™ PE 1 cap/day Supports healthy blood pressure and arterial tone
Vessel Care® PE 1 cap/day Targets homocysteine and endothelial methylation with B6, B12, folate
OmegAvail Ultra DFH 2–3 softgels/day High-potency EPA/DHA for inflammation and lipid optimization
CoQ10 (Q-Evail® or Ubiquinol) DFH 100–200 mg/day Replaces statin-depleted CoQ10, supports mitochondrial and cardiac function
Curcum-Evail® DFH 1–2 softgels/day Anti-inflammatory and endothelial-protective

🔹 Arterial Plaque Prevention / Lipid Particle Optimization
Supplement Brand Dose Purpose
Berberine Synergy™ DFH 500 mg 2x/day Reduces LDL particle number, ApoB, and improves insulin sensitivity
Monolaurin-Avail™ (optional) DFH 1 scoop/day Antimicrobial + immune support, reduces viral triggers that may contribute to vascular inflammation
L-Arginine Plus™ or Nitric Oxide Support DFH or PE 1 scoop/day (or as directed) Promotes nitric oxide synthesis and arterial flexibility (caution if on nitrates)

🔹 Statin-Specific Nutrient Support
Nutrient Depleted by statins Replace with
CoQ10 ✔️ Q-Evail (see above)
Vitamin D & K2 ✔️ Vitamin D3 + K2 (DFH): 2000–4000 IU/day
Selenium + Zinc ✔️ Found in O.N.E. Multivitamin (PE)

🧘‍♂️ EXERCISE & LIFESTYLE
Activity Goal
Cardio (walking, biking, swimming) – 30–45 min, 5x/week Improves endothelial function, lowers blood pressure
Strength training 2–3x/week Enhances insulin sensitivity, metabolic resilience
Daily breathwork or meditation (5–10 min) Reduces sympathetic tone and inflammatory markers
Sleep 7–9 hrs/night Critical for vascular repair and lipid regulation

🧪 LABS TO MONITOR (Every 3–6 Months)
Lipid panel + ApoB, LDL particle number, Lp(a)

Oxidized LDL, hs-CRP, fibrinogen

Homocysteine, Vitamin D, CoQ10, Magnesium RBC

CAC score (baseline and repeat every 5 years if needed)

EndoPAT or pulse wave velocity (if available) for arterial flexibility

🧾 SAMPLE DAILY ROUTINE
Morning

Nourish & Flourish shake + Omega-3 + Berberine + Vessel Care

30-minute brisk walk

CoQ10 + multivitamin

Midday

Clean, anti-inflammatory lunch

Curcumin + L-arginine if used

Evening

Dinner with leafy greens + olive oil

Second Berberine + magnesium or breathwork

Sleep hygiene routine

07/21/2025

Here is a functional medicine protocol for reducing arterial plaque buildup using nattokinase, integrated with:

Designs for Health (DFH)

Pure Encapsulations (PE)

Nourish & Flourish polyphenol-rich shake

Plus diet, exercise, and lifestyle support

🎯 Functional Medicine Goals
Support fibrinolysis and reduce arterial plaque load

Lower LDL particle count, ApoB, and oxidized lipids

Improve endothelial function and nitric oxide production

Reduce systemic inflammation

Prevent thrombotic events and enhance blood flow

🧪 FEATURED: NATTOKINASE
✔️ What It Does:
Breaks down fibrin and blood clots

Reduces blood viscosity

Supports healthy circulation and plaque regression

Enhances plasmin activity (natural clot buster)

✅ Dosage Guidelines:
Nattokinase: 100–200 mg (2000–4000 FU) once or twice daily

Important: Take on an empty stomach, 30–60 minutes before a meal or 2–3 hours after

⚠️ Avoid combining with anticoagulants (e.g., Eliquis, warfarin) unless under physician supervision

💊 SUPPLEMENT PROTOCOL
🔹 Fibrinolysis + Anti-Plaque Support
Supplement Brand Dose Purpose
Nattokinase NSK-SD® PE 100 mg (2000 FU) 2x/day Fibrin and clot breakdown, plaque regression
Curcum-Evail® DFH 1–2 softgels/day Anti-inflammatory and supports vascular repair
OmegAvail Ultra DFH 2–3 softgels/day Anti-inflammatory EPA/DHA, reduces plaque progression
CoQ10 (Q-Evail® or Ubiquinol) DFH 100–200 mg/day Improves endothelial function, protects against statin-induced depletion
Berberine Synergy™ DFH 500 mg 2x/day Reduces small dense LDL, ApoB, improves insulin resistance
Vessel Care® PE 1 cap/day Lowers homocysteine and supports methylation for arterial repair

🔹 Optional Add-ons for Advanced Plaque Support
Supplement Brand Dose Purpose
Arterosil® HP Designs for Health (if available) 1–2 caps/day Repairs endothelial glycocalyx (clinical-grade arterial lining support)
Niacin SR (sustained release) PE 250–500 mg/day (start low) May reduce Lp(a) and LDL particles (monitor liver enzymes)

🥗 DIET STRATEGY
✅ Emphasize:
Polyphenol-rich Mediterranean-style diet:

Berries, pomegranate, beets, leafy greens, garlic, turmeric, olive oil, wild salmon

Plant-based fiber: ground flaxseed, chia, oats, lentils

Nitrate-rich veggies: arugula, spinach, celery (for NO production)

Nourish & Flourish shake: 1x/day with beetroot powder, cinnamon, MCT oil

❌ Avoid:
Processed meat, seed oils (canola, corn, soy), refined carbs

Sugary drinks, excess sodium, and trans fats

Alcohol (limit to

07/19/2025

🧬 Do you want the age defying health benefits of calorie restriction without having to actually eat so little?

Introducing Resveratrol: a powerful polyphenol shown to activate your body’s longevity pathways, protect your cells against oxidative damage, and support brain and heart health!

Found in red grapes, peanuts, and Japanese knotweed, resveratrol has been studied for its role in:

✅ Supporting cardiovascular function
✅ Protecting memory and brain health
✅ Promoting healthy blood sugar & metabolism
✅ Reducing oxidative stress and slowing aging

Find all three recommended products here: https://solutions4health.com/search?q=resveratrol*%20AND%20product_type:*&type=product

07/18/2025

Here is a functional medicine protocol for a female in perimenopause experiencing hair loss, using:

✅ Designs for Health (DFH)

✅ Pure Encapsulations (PE)

✅ Nourish & Flourish

✅ With diet and exercise targeted to hormone balance, hair regrowth, and stress resilience

🎯 CORE GOALS
Support healthy hormone balance (estrogen, progesterone, androgens)

Address nutrient deficiencies driving hair loss

Lower inflammation and cortisol

Stimulate hair follicle recovery and growth

🧬 SUPPLEMENT PROTOCOL
🔹 1. HORMONE & STRESS SUPPORT
PE Hormone Balance – 1 cap 2x/day
➤ DIM, calcium-D-glucarate, broccoli seed extract for estrogen metabolism

S4H FemGuard+Balance™ – 2–4 caps/day
➤ Supports progesterone balance, detoxification, and adrenal function

PE Cortisol Calm – 1–2 caps at night or late afternoon
➤ Magnolia, ashwagandha, and l-theanine help modulate stress-driven hair loss

🔹 2. HAIR REGENERATION + NUTRIENT SUPPORT
PE Hair/Skin/Nails Ultra – 2 caps/day
➤ Biotin, silica, zinc, and collagen cofactors for keratin support

DFH Complete Multi™ or PE PureNutrients – 2–4 caps/day
➤ Methylated B vitamins, iron, zinc, selenium – all critical for follicle activity

PE Iron-C (if ferritin < 70 ng/mL) – 1 cap/day with vitamin C
➤ Low ferritin is a major driver of hair shedding in women

DFH OmegaAvail™ Ultra – 2 softgels/day
➤ Omega-3s lower inflammation and support scalp circulation

Nourish & Flourish Shake – 1 scoop/day
➤ Clean protein, micronutrients, adaptogens to fill gaps and support metabolism

🔹 3. OPTIONAL BOOSTERS
DFH Hydrolyzed Collagen or PE Collagen JS – 10–20 g/day
➤ Strengthens dermis and scalp structure

PE Inositol Powder – 2–4 g at night
➤ Especially helpful if insulin resistance or PCOS-like hair loss suspected

Topical rosemary oil or minoxidil can be added locally for scalp stimulation

🥗 DIET STRATEGY
✅ FOCUS ON:
Protein: ≥ 80–100g/day (eggs, wild salmon, poultry, lentils, collagen shakes)

Iron-rich foods: grass-fed beef, spinach, pumpkin seeds

Zinc-rich foods: oysters, seeds, lamb, chickpeas

Estrogen-balancing foods: flaxseeds, cruciferous vegetables, organic soy (if tolerated)

Hair & hormone healthy fats: avocado, extra virgin olive oil, walnuts

🚫 AVOID:
Sugar and refined carbs (insulin surges → increased DHT)

Alcohol and caffeine excess (depletes B vitamins, raises cortisol)

Processed foods with seed oils and additives

🏋️ EXERCISE
Type Frequency Benefit
Resistance training 3x/week Supports lean mass, improves hormone balance
Walking/Zone 2 cardio 30 min/day Enhances circulation and fat metabolism
Yoga or breathwork 2x/week Modulates cortisol and improves HPA axis resilience

🧪 LABS TO CONSIDER
Test Optimal Range
Ferritin 70–120 ng/mL for hair growth
TSH, Free T3, Free T4 Optimal thyroid function (TSH < 2.0)
Estradiol, Progesterone Test on Day 21 of cycle (if regular)
DHEA-S, Testosterone To rule out androgenic hair loss
Cortisol (saliva or DUTCH) For HPA axis stress
Vitamin D 50–80 ng/mL
Zinc, Magnesium RBC or serum levels to ensure sufficiency

07/18/2025

Here is a targeted functional medicine protocol for a 56-year-old male addressing:

Pre-diabetes

Weight loss

Anxiety

Using:

✅ Designs for Health (DFH)

✅ Pure Encapsulations (PE)

✅ Nourish & Flourish

✅ Including structured diet and exercise

🎯 PRIMARY GOALS
Normalize blood glucose & A1c

Reduce visceral fat and insulin resistance

Support mood and stress regulation

Rebuild metabolic resilience

🧬 SUPPLEMENT PROTOCOL
🔹 BLOOD SUGAR & INSULIN SUPPORT
DFH GlucoSupreme™ Herbal – 2 caps with each meal
➤ Berberine, gymnema, banaba – lowers postprandial glucose, improves insulin signaling

PE Metabolic Xtra – 1–2 caps/day
➤ Chromium, alpha-lipoic acid, cinnamon – supports insulin sensitivity and fat metabolism

DFH Sensitol™ – 2 caps 2x/day
➤ Myo-inositol + D-chiro-inositol – improves glucose uptake and reduces anxiety symptoms

🔹 ANXIETY, STRESS & SLEEP SUPPORT
PE L-Theanine – 200 mg up to 2x/day as needed
➤ Calming without sedation; modulates alpha brain waves

DFH NeuroCalm™ or GABAnol™ – 2 caps in the evening or as needed
➤ GABA, glycine, taurine – supports parasympathetic tone, reduces anxiety, improves sleep

PE Cortisol Calm – 1–2 caps mid-afternoon or at night
➤ Ashwagandha, magnolia – reduces cortisol and emotional reactivity

🔹 NUTRITIONAL & CELLULAR SUPPORT
PE PureLean Nutrients – 2–4 caps/day
➤ Advanced multi with metabolic, adrenal, and antioxidant support

DFH OmegAvail™ Ultra – 2 softgels/day
➤ Omega-3s reduce inflammation, support blood sugar, mood, and triglycerides

Nourish & Flourish Shake – 1 scoop 1–2x/day (can replace breakfast or lunch)
➤ Macronutrient-balanced with protein, fiber, micronutrients, adaptogens

🥗 DIET RECOMMENDATIONS
✅ EMPHASIZE:
Modified Mediterranean/Low-Glycemic Diet

40% vegetables, 25–30% protein, 20–30% healthy fats, 5–10% low-glycemic carbs

High-fiber foods: lentils, leafy greens, chia, flax

Healthy fats: olive oil, avocado, nuts, seeds

Protein at each meal: wild fish, poultry, eggs, legumes

Fermented foods (if tolerated): kefir, kimchi, sauerkraut

Cinnamon, vinegar, and bitter greens to blunt post-meal glucose spikes

🚫 AVOID:
Refined carbs, bread, soda, alcohol

Skipping meals or grazing (disrupts insulin balance)

Artificial sweeteners (can worsen insulin sensitivity)

High histamine foods if anxiety worsens

🏋️ EXERCISE PROTOCOL
Type Frequency Benefits
Resistance training 2–4x/week Builds muscle, improves insulin sensitivity
Zone 2 cardio (brisk walking, cycling) 150–180 min/week Fat burning, cardiovascular health
High-Intensity Intervals (HIIT) 1–2x/week (optional) Increases VO2 max, insulin response
Yoga / deep breathing 2–3x/week Cortisol reduction, vagus nerve support

🧪 KEY LABS TO MONITOR
Test Optimal Target
Fasting Glucose 75–89 mg/dL
Hemoglobin A1c ≤ 5.3%
Fasting Insulin < 8 µIU/mL
hs-CRP < 1.0 mg/L
Cortisol (saliva or DUTCH) Normal rhythm
Omega-3 Index > 8%
Vitamin D 50–80 ng/mL

🔄 OPTIONAL ADD-ONS
Continuous Glucose Monitor (CGM) for feedback

Mindfulness apps (e.g. Breathwrk, Insight Timer)

Infrared sauna or cold showers for metabolic and nervous system conditioning

07/17/2025

Here is a functional medicine protocol for an 84-year-old male recovering post-pneumonia, currently taking:

Blood pressure medication

Statin

Antibiotics (likely short-term)

Using:

✅ Designs for Health (DFH)

✅ Pure Encapsulations (PE)

✅ Nourish & Flourish

✅ Including anti-inflammatory diet and gentle movement

🎯 FUNCTIONAL GOALS
Restore lung and immune function

Rebuild gut microbiome post-antibiotics

Reduce inflammation and oxidative stress

Support muscle strength and nutrient repletion

Protect against future respiratory and cardiovascular events

🧬 SUPPLEMENT PROTOCOL
🔹 1. Immune & Lung Recovery
DFH ImmunoMod-A™ – 2 caps/day
➤ Beta-glucans, NAC, and mushroom extracts to regulate immune function post-infection

PE NAC 600 mg – 1–2 caps/day
➤ Loosens lung mucus, restores glutathione, antioxidant support

PE Quercetin UltraSorb – 500 mg/day
➤ Lung tissue support, histamine control, anti-inflammatory

🔹 2. Post-Antibiotic Gut Restoration
DFH ProbioMed™ 50 or 100 – 1 cap/day for 2+ months
➤ Broad-spectrum, high-potency probiotic

DFH GI Revive® Powder – 1 scoop/day
➤ Soothes and restores gut lining integrity

Nourish & Flourish Shake – 1 scoop/day
➤ Replenishes protein, micronutrients, antioxidants; can be breakfast or afternoon snack

🔹 3. Anti-inflammatory & Mitochondrial Support
DFH OmegAvail™ Ultra – 2 softgels/day
➤ Cardiovascular and anti-inflammatory omega-3 support

PE Resveratrol VESIsorb® – 1 cap/day
➤ Protects endothelial cells, supports statin users’ mitochondrial health

PE CoQ10 100 mg (or DFH CoQnol™ 100) – 1 cap/day
➤ Offsets statin-induced mitochondrial depletion

🔹 4. Nutrient & Muscle Rebuilding
PE Magnesium Glycinate – 200–400 mg at bedtime
➤ Supports sleep, cardiovascular tone, and muscle recovery

PE Multi T/D – 2–4 caps/day
➤ Provides methylated B vitamins, minerals, and antioxidants in a daily multi

PE Creatine Monohydrate (optional) – 3–5 g/day
➤ Supports muscle strength, recovery, and cognition in elderly patients

🥗 DIET RECOMMENDATIONS
✅ Emphasize:
High-protein intake: eggs, wild salmon, chicken, legumes, protein shakes (1.0–1.2 g/kg/day)

Polyphenol-rich fruits/veggies: berries, spinach, garlic, onions, pomegranate, broccoli

Fermented foods (if tolerated): kefir, sauerkraut, yogurt

Olive oil, avocados, walnuts: healthy fats for inflammation and satiety

Bone broth or collagen (gut and connective tissue repair)

🚫 Avoid:
Processed sugars and refined grains (immune suppression)

Dairy (if mucus-producing)

Excess sodium (watch BP)

🏃‍♂️ EXERCISE & LIFESTYLE
Gentle daily walking: start with 5–10 minutes, aim for 20–30 min/day

Breathing exercises: pursed-lip or diaphragmatic breathing 2–3x/day

Chair-based resistance (if mobility limited): light weights or resistance bands

Sleep hygiene: 7–9 hours in a dark, cool, quiet room

Sunlight: 15–20 minutes daily for circadian and vitamin D support

🧪 LABS TO MONITOR
Test Purpose
CBC, CMP Baseline post-infection, electrolytes, organ function
Lipid panel, ApoB Statin effectiveness
hs-CRP Inflammation
Vitamin D Immune regulation
Omega-3 Index Cardiovascular risk
Stool test (GI MAP) If persistent GI symptoms post-antibiotics

07/16/2025

Yes — here’s a breakdown of the most compelling clinical evidence that nattokinase at sufficiently high doses can significantly reduce arterial plaque:

🩸 Key Clinical Study – 1,062 Participants (Chinese Cohort)
Dose: 10,800 FU daily — much higher than typical 2,000 FU doses
Wikipedia
+14
PMC
+14
greenmedinfo.com
+14

Results (after 12 months):

Carotid Intima-Media Thickness (CCA‑IMT) decreased from 1.33 to 1.04 mm (~21.7% reduction)
Verywell Health
+7
PMC
+7
ResearchGate
+7

Carotid plaque size dropped by ~36%
ResearchGate
+13
PMC
+13
nmn.com
+13

Lipid improvements:

LDL‑C down ~18%, TC ~16%, TG ~15.7%

HDL‑C up ~15.8%
PMC

Key Insight: Lower doses (~3,600 FU/day) were ineffective — benefits were strongly dose-dependent
ClinicalTrials.gov
+7
PMC
+7
PubMed
+7

🧠 Additional Clinical and Mechanistic Evidence
A 26-week RCT compared nattokinase (6,000 FU/day) to simvastatin — showing significant reductions in carotid plaque and IMT, with ~36.6% plaque reduction vs 11.5% in the statin group
Fight Aging!
+1
ScienceDirect
+1

Meta-analyses confirm notable antiatherosclerotic and lipid-lowering effects, with cardiovascular benefits linked to direct fibrinolysis, anti-inflammation, and improved lipid metabolism
ResearchGate

🔍 Summary in Context
High-dose nattokinase (≥10,800 FU/day) has been shown to:

Reduce carotid plaque size by ~36%

Lower CCA‑IMT by ~22%

Improve LDL, triglycerides, and HDL significantly

Lower doses (

Solutions 4 Health

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