Sosa International Consultant Services - SICS

08/24/2025

Plastic pollution is now an emerging issue worldwide, and the amount of plastic debris is rapidly increasing day by day in this decade. The surface of plastic contains a wide variety of biofilm-forming microorganisms that can pose a risk to human health. Studies showed that Escherichia coli is resis...

07/29/2025

The global epidemiology of carbapenem-resistant Acinetobacter baumannii

Carbapenem-resistant Acinetobacter baumannii (CRAb) is a challenging, environmentally hardy organism with a
propensity to spread within hospitals and a predilection to infect critically ill, vulnerable patients. With its potential
for rapid transmission, limited treatment options, and substantial mortality, CRAb is recognized as a critical,
top-priority pathogen. Since its initial discovery in 1985, CRAb has disseminated globally, presenting a significant
public health threat. CRAb is now endemic in many regions in Europe, South America, Asia, and Africa and globally
contributes to over 50 000 deaths each year. Its ability to adhere to hospital surfaces, withstand desiccation,
and form biofilms leads to widespread outbreaks. At-risk populations include those hospitalized and
ventilated, and the most frequent presentations are respiratory and bloodstream infections. Carbapenem resistance
in CRAb is primarily mediated by plasmid-borne carbapenemase genes, especially blaOXA-23. These genes,
carried by several epidemic international clones, including IC1 and IC2, have facilitated the global dissemination
of CRAb through horizontal gene transfer in healthcare settings. Mortality rates are >20% and vary substantially
by region and by type of infection, with bloodstream infections carrying >40% mortality. Despite its significant
impact, the development of treatments for CRAb remains inadequate. The novel agent sulbactam-durlobactam
holds promise for improved patient outcomes, but ongoing therapeutic development, infection prevention, and
antimicrobial stewardship are critical to combat this formidable pathogen. Here, we review the emergence and
dissemination of CRAb, its molecular epidemiology and resistance mechanisms, summarize contemporary global
clinical epidemiology and patient outcomes, and briefly describe existing and future therapeutics.

05/09/2025

Howard et al. demonstrate that clinical isolates of the opportunistic pathogen Pseudomonas aeruginosa can encode functional plastic-degrading enzymes and that these enzymes can influence bacterial biofilm formation.

05/09/2025

Pseudomonas aeruginosa

"We need to understand the impact this had on patient safety," said biomedical scientist Ronan McCarthy.

04/28/2025

Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infection in mice.

04/24/2025

Vaccines have saved 154 million lives globally since the launch of the Expanded Programme on Immunization by the World Health Organization in 1974 and are one of the great triumphs of medicine. Sadly, vaccine skepticism in the USA has helped drive distrust of vaccines in other parts of the world, th...

04/21/2025

Fiebre Tifoidea extremadamente resistente a los antibióticos

Typhoid fever might be rare in developed countries, but this ancient threat, thought to have been around for millennia, is still very much a danger in our modern world.

04/10/2025

These pathogens put millions of lives and modern medicine at risk.

Learn more about the threats and how we can take action: https://bit.ly/42pacHI

04/02/2025

This blog provides insights from the antibiotic resistance workshop in Bangalore, hosted by OHT in collaboration with the Trinity Challenge.

04/02/2025

Jetzt anmelden: INFECTIONS - Symposium “Antimicrobial resistance: The silent pandemic” 🦠 In den letzten Jahrzehnten konnten Infektionskrankheiten in Industrieländern durch bessere Hygiene, Prävention und Antibiotika deutlich zurückgedrängt werden. Doch die zunehmende antimikrobielle Resis...

04/02/2025

The U.S. has scaled back foreign aid, and the consequences could be dire. Without funding for antimicrobial resistance programs, the world faces a growing crisis — one where infections once easily treated become untreatable, experts warn.

04/02/2025

"What are the benefits of addressing in Schools? →Healthy students with less likelihood of infections through simple actionable behaviour change. → Promoting healthy, sustainable school environments and reducing the spread of resistance among humans, animals and environments. → Educa...