10/21/2025
🎃 Ask Dr. Matt: What are the most common hormone disruptors?
1. Plastics: BPA and phthalates
BPA can act on estrogen pathways and is widely characterized as an endocrine disruptor. Phthalates are linked to anti-androgenic effects and broader hormonal interference. [PMID: 23994667, PMC8157593]
2. Pesticides and herbicides
Multiple pesticide classes can interfere with thyroid and s*x hormone action, which matters for energy, mood, metabolism, and development. Reviews highlight thyroid-disrupting effects and broad endocrine activity. [PMID: 37956907, PMC6915086] PubMed+1
3.Personal care chemicals: parabens and fragrance solvents
Parabens show measurable but weak estrogenic activity and can interact with estrogen-related enzymes. The weight of evidence in cosmetics is debated, yet they are still categorized as endocrine active compounds in the literature. [PMID: 16097138, PMC5618656]
4. Excess sugar and refined carbs
Frequent sugar spikes drive insulin resistance, which can disrupt ovarian hormones in PCOS and correlate with lower testosterone in men with metabolic syndrome. [PMID: 28416368, PMC3474619]
5. Poor sleep and chronic stress
Short sleep shifts appetite hormones, with ghrelin rising and leptin falling, which fuels cravings and metabolic stress. Psychological stress can also suppress reproductive signaling at the level of GnRH and downstream gonadotropins. [PMID: 36404495, PMC9232848]
- Dr. Matt Beyer