EpiCypher Inc.

EpiCypher Inc. EpiCypher is a bioscience company developing unique reagents and services for chromatin biology and epigenetics research.

A pioneer in the field of epigenetics and chromatin biology, EpiCypher is a bioscience company developing transformative technologies and delivering superior products to researchers world-wide. Our technologies and products are making studies possible that were not imaginable just a few years ago. Our innovation is a direct result of the scientific power associated with EpiCypher. Our renowned chromatin researchers possess expertise and unique insight into epigenetics that benefit our customers in ways other companies cannot. Arising from an abundance of demand for high quality products from the laboratories of Mark Bedford, Brian Strahl, and Or Gozani EpiCypher was founded on January 18, 2012 as a spin-out from University of North Carolina at Chapel Hill. Starting with the groundbreaking and proprietary histone peptide array platform, EpiGold™, EpiCypher has developed a wide portfolio of best in class products. EpiCypher's mission is to develop products to enable researchers to complete experiments that are not otherwise possible.

🔥 Advancing your DNA methylation research?Discover the next generation of CUTANA™ DNA methylation tools designed for sca...
02/23/2026

🔥 Advancing your DNA methylation research?

Discover the next generation of CUTANA™ DNA methylation tools designed for scalable, high-resolution epigenomic profiling:

🧬 meCUT&RUN
Target and enrich methylated DNA for genome-wide analysis with dramatically reduced sequencing requirements compared to traditional approaches.

🔎 Multiomic CUT&RUN
Simultaneously profile DNA methylation and chromatin proteins in a single workflow, revealing epigenetic crosstalk from the same sample.

Ready to integrate methylation and chromatin insights in one streamlined experiment? Explore what’s possible.
👉 https://www.epicypher.com/products/dna-methylation-sequencing-assays/

How do enhancers find their target promoters? How expansive is the regulatory landscape governing transcription? 🧬We’re ...
02/19/2026

How do enhancers find their target promoters? How expansive is the regulatory landscape governing transcription? 🧬

We’re pleased to sponsor the upcoming Fragile Nucleosome Seminar Series on February 25 at 9am PST.

Pavan Choppakatla will discuss loop extrusion and distal enhancer–promoter search, and Jill Moore will present an expanded registry of candidate cis-regulatory elements for studying transcriptional regulation.

Join the seminar and connect with the chromatin community.
Register here: https://us06web.zoom.us/webinar/register/WN_i4n53UTdQLO8okWVfykxJQ

The replay is now available 🎥As part of the 2026 Fragile Nucleosome seminar series, EpiCypher’s Chief Scientific Officer...
02/18/2026

The replay is now available 🎥

As part of the 2026 Fragile Nucleosome seminar series, EpiCypher’s Chief Scientific Officer, Michael-Christopher Keogh, PhD, presents The path to a histone PTM landscape of the mouse immune system.

In this session, Michael discusses how chromatin profiling strategies can uncover new insights into immune cell regulation and epigenetic complexity.

Watch the full seminar on YouTube and stay connected with the latest in chromatin research.

🔗 https://youtu.be/JxlLsmAa2jo

📄 New co-authored publication in Genes & DevelopmentPolycomb group proteins have been central to developmental biology r...
02/17/2026

📄 New co-authored publication in Genes & Development

Polycomb group proteins have been central to developmental biology research for decades. In a new study by Patriotis et al., researchers demonstrate that the conserved N-terminal SANT1-binding domain of EZH2 is required for proper PRC2 activity and genome-wide H3K27 methylation, with relevance to EZH2-driven lymphomas.

We are proud that this work features EpiCypher’s Captify™ platform and honored to contribute to the scientific legacy of Dr. C. David Allis.

Read more: https://doi.org/10.1101/gad.353070.125

We’re heading to Montgomery College Bioscience Education Center for MC Biotech Day on February 18, 2026.Join Emily A. Ma...
02/16/2026

We’re heading to Montgomery College Bioscience Education Center for MC Biotech Day on February 18, 2026.

Join Emily A. Madden, PhD, Product Manager at EpiCypher, for a talk on how Fiber-seq uses leverages direct long-read sequencing to assess chromatin accessibility and DNA methylation across the genome and at single molecule resolution.

Talk title: Whole-genome epigenomics with single-molecule resolution
📅 Feb 18 | ⏰ 11:00–11:30am

The presentation will highlight how Fiber-seq can support genome-wide discovery while retaining the resolution needed to infer protein binding and inform regulatory mechanisms.

If you study gene regulation and want to understand how DNA sequence, chromatin accessibility, and regulatory protein binding interact across the genome, this talk is for you. Attendance is free, but registration is required.

Register here: https://forms.office.com/pages/responsepage.aspx?id=SjmSTFxSGk2CZ5NhDCTcedGKUx5CuIFOkoio8v468_dUQk9MMlBJMFMzRjJDVTAxUFZDS1EzRThFNy4u&route=shorturl

This Valentine’s Day, don’t go it alone when bringing a new assay into your lab.Fiber-seq custom services pair your team...
02/14/2026

This Valentine’s Day, don’t go it alone when bringing a new assay into your lab.

Fiber-seq custom services pair your team with an EpiCypher expert who provides hands-on guidance as you establish Fiber-seq in your own lab. We advise on experimental design, assay setup, and best practices, and support bioinformatics onboarding so you can generate and interpret high-quality data with confidence.

Because the strongest results come from a good partnership. ❤️

Learn more about Fiber-seq custom services: https://www.epicypher.com/services/cutana-fiber-seq-assay-services/

We were honored to welcome Dr. Steve Henikoff, Professor at Fred Hutchinson Cancer Center and HHMI Investigator, to EpiC...
02/13/2026

We were honored to welcome Dr. Steve Henikoff, Professor at Fred Hutchinson Cancer Center and HHMI Investigator, to EpiCypher for an internal seminar on “Epigenomic profiling for personalized medicine.” 🔬

Dr. Henikoff’s visit sparked engaging discussions across our genomics, product, services, and innovation teams. Opportunities to exchange ideas with leaders in epigenomics strengthen our shared mission to advance chromatin science.

We are grateful for his time, insight, and collaboration. 🧬

Today is International Day of Women and Girls in Science, a time to celebrate the women whose research, leadership, and ...
02/11/2026

Today is International Day of Women and Girls in Science, a time to celebrate the women whose research, leadership, and mentorship continue to shape the future of discovery. 🔬✨

From the bench to the broader scientific community, their contributions move science forward and inspire the next generation to pursue bold ideas. We’re proud to support a research community where curiosity, collaboration, and inclusion go hand in hand. 💖

We’re celebrating a new co-authored publication in ACS Central Science: “Direct Readout of Multivalent Chromatin Reader-...
02/10/2026

We’re celebrating a new co-authored publication in ACS Central Science: “Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry” (Lee et al., 2026; DOI: 10.1021/acscentsci.5c00736) 🎉

This work showcases Nuc-MS for directly characterizing chromatin-associated protein:nucleosome complexes and highlights distinct enrichment profiles across different readers. We’re proud that it also flows from our dNucs™ (including heterotypic nucleosomes) and Captify™ programs, and from an ongoing collaboration with the Kelleher lab.

On February 11 at 9:00 am PST, the Fragile Nucleosome Seminar Series brings together leading scientists to explore these...
02/09/2026

On February 11 at 9:00 am PST, the Fragile Nucleosome Seminar Series brings together leading scientists to explore these mechanisms, with talks from Siddhartha G. Jena (Broad Institute) and Bluma J. Lesch (Yale School of Medicine).

We are proud to sponsor this seminar and support open scientific exchange in the chromatin community. 🔬
👉 Register to attend: https://us06web.zoom.us/webinar/register/WN_i4n53UTdQLO8okWVfykxJQ

🧪 Using EpiCypher reagents for DIY CUT&RUN or CUT&Tag?Our updated DIY protocols for CUT&RUN and CUT&Tag are now live! Ou...
02/09/2026

🧪 Using EpiCypher reagents for DIY CUT&RUN or CUT&Tag?

Our updated DIY protocols for CUT&RUN and CUT&Tag are now live! Our updated protocols include improved handling guidance, refined bead ratios, and integration of the new CUTANA™ Wash Buffer Enhancer Set to reduce variability—especially for nuclei inputs.

You’ll also notice we now use CUTANA™ DNA Purification Beads as a drop-in replacement for SPRIselect, validated for CUT&RUN, CUT&Tag, and NGS library prep (with the same bead ratios and room-temperature storage).

If you’re running DIY CUT&RUN or CUT&Tag, these updates are designed to make your workflow smoother and your data more reproducible. Check out the new protocols and let us know what you think! 👇💬

Recently, our CSO Michael-Christopher Keogh, PhD visited New England Biolabs to present a talk on multi-omic studies of ...
02/06/2026

Recently, our CSO Michael-Christopher Keogh, PhD visited New England Biolabs to present a talk on multi-omic studies of chromatin function. His presentation explored how histone modifications, nucleosome context, transcription factors, DNA methylation, and accessible genomic regions intersect to regulate the genome.

We thank NEB for hosting Michael and for being excellent scientific collaborators and commercial partners. 🔬🧬

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6 Davis Drive
Durham, NC
27709

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+18553742461

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