Polarean, Inc.

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Durham, NC
Polarean, Inc.

Comprehensive Imaging of Lung Function in One Breath We are committed to making this capability available in your lab and putting it under your control.

Polarean has acquired the key assets and intellectual property for commercializing hyperpolarized gas MRI technology. By enabling leading academic institutions and industry scientists to freely pursue innovative ideas and applications we seek to unlock the extraordinary promise of this novel technology. Whether it’s basic physics, chemistry, or clinical imaging, our mission is to encourage adoption and exploration of hyperpolarized gas technology.

10/24/2025

💙 Today is BOS Education Day! A day dedicated to advancing understanding and supporting innovation in Bronchiolitis Obliterans Syndrome (BOS) — the leading cause of chronic lung allograft dysfunction (CLAD) and one of the most significant challenges in post-lung transplant care worldwide.

According to the Lung Transplant Foundation, BOS affects up to half of lung transplant recipients within five years after transplant, and early detection of BOS improves long-term outcomes for transplant recipients.

At Polarean, we’re proud to collaborate with the Lung Transplant Foundation and the broader transplant community to drive progress through education and innovation. Last year’s BOS Education Day webinar, “New and Emerging Technologies and Research,” explored how advanced functional imaging is helping clinicians detect and monitor BOS earlier.

💚 Watch the webinar to learn more about how may provide deeper functional insights beyond traditional pulmonary function tests in monitoring for BOS. Knowledge is Power.

🔗 https://lungtransplantfoundation.org/resources/technologies-and-research/

10/20/2025

It was an exciting week at Cincinnati Children's, where the first clinical Xenon MRI scan in a child under 12 was performed following the expanded pediatric label for patients ages 6+ and using the newly released pediatric Dose Delivery Bags. 👏

On Thursday, an 8-year-old girl underwent the scan, marking an important milestone in extending the benefits of functional lung imaging to younger patients. provides unique, radiation-free insights into how air moves through the lungs, revealing subtle ventilation changes that traditional imaging often cannot detect.

The day began with Research Assistant Mary McNeill preparing the Xenon dose, followed by expert care in the MRI suite from technologists Rachael Young and Madison Huber, and nurse Ashley Broering, RN. On site to witness this important moment were Chris von Jako, Brady Anna, and pulmonary imaging scientists Professors Zackary Cleveland and Matthew Willmering.

The team also followed this milestone by scanning an adult patient referred from UC Health across the street, highlighting how Xenon MRI serves patients across the full spectrum of lung disease, from childhood through adulthood.

✨ This first under-12 clinical scan marks an exciting step in expanding access to advanced functional lung imaging and improving respiratory care for patients of all ages.

Discover more: Polarean.com

10/15/2025

🗓️ Tomorrow’s the Day!

Join us October 16 at 12:00 PM ET for our live webinar:
Lung Imaging with Xenon MRI in Children: Building a Successful Clinical Program

This is your chance to hear directly from Cincinnati Children's, the first institution to pioneer clinical Xenon MRI. The session will explore how pediatric radiology teams are integrating Xenon MRI to transform lung imaging and elevate patient care.

Why Attend:
✔ Practical insights from real-world pediatric case studies
✔ Step-by-step implementation strategies across radiology and multidisciplinary teams
✔ Workflow integration using multinuclei MR capabilities
✔ Reimbursement pathways to support sustainable program growth

📢 It’s not too late to save your spot!

👉 Register now: https://www.xenon-mri.com/webinar

10/14/2025

When Spirometry Isn’t Enough, Xenon MRI Detects Subtle Changes

Breakthrough cystic fibrosis ( ) treatments like ETI therapy (Elexacaftor/Tezacaftor/Ivacaftor), which target CFTR protein defects, have transformed patient care. Many people with CF now achieve normal lung function (FEV₁ ≥ 80%)—a remarkable shift that brings new questions:

☑️ Is there ongoing benefit to maintaining ETI therapy?
☑️ Can burdensome airway clearance be reduced?
☑️ Can small, continuous improvements be measured and quantified?

Traditional spirometry may no longer be sensitive enough to fully answer these questions or to serve as a meaningful endpoint in clinical trials involving people with mild lung disease.

A new report from Cincinnati Children's shows that can detect subtle, regional ventilation abnormalities that spirometry may miss. Over one year of ETI therapy, people with CF demonstrated ventilation improvements on Xenon MRI, even among those with minimal disease on conventional tests.

These findings highlight Xenon MRI’s potential as a sensitive biomarker of therapeutic efficacy, complementing traditional endpoints when changes are subtle but clinically meaningful.

🔗 Read the full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469796/

Vertex

10/09/2025

🌟 Making History Together: The First Lung Transplant Awareness Day 🌟

Today, October 9, 2025, marks the inaugural Lung Transplant Awareness Day: Inhale Gratitude. Exhale Hope.

For thousands living with advanced lung disease, a lung transplant represents hope and a second chance at life. Yet awareness and understanding of this life-saving treatment remain far too limited.

This historic day honors the patients and families who embody strength and resilience, and the clinicians and donors whose skill, courage, and generosity make new beginnings possible.

At Polarean, we are proud to stand with the Lung Transplant Foundation and the broader lung health community as advocates in this important first year.

Our platform helps provide functional insights across multiple stages of the transplant journey:
✨ Pre-transplant: Optimize patient selection and surgical planning
✨ Early post-op: Establish baselines and detect mild complications
✨ Longitudinal: Identify chronic lung allograft dysfunction (CLAD) earlier to enable timely treatment

Together, we celebrate this milestone and look ahead to building a legacy of awareness, education, and hope for the lung transplant community.

🔗 Learn more: lungtransplantawarenessday.org

10/08/2025

⏰ Almost One Week Away!

Join us on October 16 at 12 PM ET for a webinar hosted in partnership with Philips, featuring experts from Cincinnati Children's:
· Erik Hysinger, MD
· Jason Woods, PhD
· R. Paul Guillerman, MD
· Cara Morin, MD, PhD

Discover how is transforming lung imaging and hear firsthand insights from the team that pioneered its clinical use.

What you’ll learn:
✔ Clinical value in pediatrics, illustrated through real-world case studies
✔ Workflow integration, featuring Philips multinuclei MR capabilities
✔ Implementation strategies across radiology and multidisciplinary teams
✔ Economic considerations, including reimbursement and program planning

➡️ Register here to watch live: https://www.xenon-mri.com/webinar

Images adapted from: Radiology: Cardiothoracic Imaging 2025; 7(4):e240562

09/29/2025

🚀 The Polarean team is on the ground at , where the future of lung cancer care is on display.

New research in Advances in Radiation Oncology from the American Society for Radiation Oncology highlights how functional lung imaging is reshaping radiation therapy.

The study demonstrates how Xenon MRI can:

✅ Detect early ventilation and gas exchange changes within weeks after RT

✅ Support functional avoidance planning to protect healthy lung

✅ Monitor for radiation-induced injury with a new level of sensitivity

As thousands of oncologists and researchers gather at ASTRO’s 2025 Annual Meeting, this work underscores that functional imaging with Xenon MRI is not only complementary to CT and PET, but has the potential to transform how we plan and monitor radiation therapy for lung cancer.

📩 Contact us at info@polarean.com to meet with our team during ASTRO. You can also connect directly with Alan Huang, PhD, and Daniel Booker while on site.

📖 Read the full study: https://doi.org/10.1016/j.adro.2025.101810

09/25/2025

🌍 Today on World Lung Day, we join the call for Healthy Lungs, Healthy Life.

The theme of Bridging the Gap highlights the importance of moving from awareness to action and from detection to treatment. Closing gaps in diagnosis and care helps ensure that more people worldwide can live healthier lives.

At Polarean, we are advancing this mission with our lung imaging platform ( ), which provides clinicians and patients with a new way to visualize how the lungs function. These functional insights can reveal information that traditional tests may miss, supporting earlier detection, more precise monitoring, and more informed care decisions.

Together with patients, providers, and advocates, the Forum of International Respiratory Societies - FIRS and the Global Lung Function Initiative, we are working toward a future where everyone has the opportunity for healthier lungs and a healthier life.

Learn more: https://firsnet.org/world-lung-day-2025/

09/24/2025

🌟 Join us for a live Webinar — Lung Imaging with Xenon MRI in Children: Building a Successful Clinical Program 🌟

📅 Date: October 16, 2025
🕛 Time: 12:00 PM ET

The recent FDA label expansion of ® to include children ages 6+ opens the door for radiology departments to deliver noninvasive functional lung imaging for more pediatric patients.

Experts from Cincinnati Children's, the first institution to pioneer clinical imaging with , will share:

✔ How Xenon MRI enhances patient care and expands radiology service lines
✔ Real-world pediatric case studies from pulmonology and radiology
✔ Practical steps for implementation and workflow integration
✔ Economic case for adoption, including reimbursement and revenue potential

Don’t miss this opportunity to learn how your institution can bring cutting-edge lung imaging into practice!

👉 Register here: https://www.xenon-mri.com/webinar

09/16/2025

🚀The American Society for Radiation Oncology (ASTRO) Annual Meeting brings together thousands of radiation oncology professionals, researchers, and industry leaders, all united by a mission to shape the future of cancer care.

At Polarean, we’re proud to be part of that conversation.

We’re attending ASTRO 2025 to connect with forward-thinking clinicians, scientists, and partners who are redefining how we see and treat the lungs. With our platform, we're helping advance:

🌠 Functional lung avoidance — enabling precision in radiation therapy by identifying and protecting the healthiest lung tissue.

🌠 Earlier recognition of radiation pneumonitis — empowering earlier interventions to support patient outcomes.

Passionate about advancing oncology and lung health? Let’s connect. Reach out to Dr. Alan Huang and Daniel Booker at the event, or schedule time with them here: xenon-mri.com

Let’s shape the future of functional imaging together.

09/10/2025

Today, September 10, we shine a light on pulmonary fibrosis (PF) and other interstitial lung diseases (ILDs), conditions where inflammation and scarring of lung tissue make it harder for oxygen to move through the body.

ILD Day was created to elevate understanding of these serious conditions. It is presented by a collaboration of patient organizations, including the Pulmonary Fibrosis Foundation, Arthritis Foundation, Foundation for Sarcoidosis, The Myositis Association, PF Warriors - Pulmonary Fibrosis, IPF, other Rare Lung Diseases, National Scleroderma Foundation, Sjögren's Foundation, and others. Together, these groups unite communities living with ILD to share knowledge, highlight treatment challenges, and drive action.

At Polarean, we are proud to stand with the ILD community. Our Xenon MRI platform provides functional insights into how gas moves through the lungs. This is information that is not available from traditional imaging methods.

In investigational use, Xenon MRI offers a unique view of gas exchange by evaluating how inhaled gas crosses the lung tissue membrane and reaches red blood cells. These functional imaging biomarkers are sensitive to early changes, detecting regional gas transfer abnormalities even in areas that appear normal on CT or when pulmonary function tests remain unchanged. While labeled investigational today, these measures support characterization of fibrosis, tracking of disease activity, and evaluation of therapy response.

We are honored to support patients, caregivers, and researchers in the shared mission of advancing awareness, education, and innovation for ILD.

🔗 Learn more: https://www.pulmonaryfibrosis.org/get-involved/events/ild-day

09/09/2025

How are you currently evaluating mucus plugs? 💭

This was a central question during our recent webinar, now available to watch on demand with registration: https://www.xenon-mri.com/post-webinar

Led by renowned experts Parameswaran Nair, MD, PhD, Sarah Svenningsen, PhD, and Mario Castro, MD, MPH, the session explored cutting-edge research and clinical strategies, including:

➡️ How mucus plug-related imaging biomarkers correlate with disease activity, remodeling, and therapeutic response
➡️ The role of Xenon MRI in precision medicine for asthma and COPD
➡️ When and how to integrate functional lung imaging in clinical and research settings
➡️ Real-world case studies showing how imaging biomarkers can guide biologic therapy decisions

This webinar is valuable for pulmonologists, radiologists, respiratory researchers, and drug development teams seeking to advance patient stratification and improve understanding of therapy response in obstructive lung disease.

💬 Join the conversation: How are you approaching mucus plug imaging in your clinical practice or research?

Address

2500 Meridian Pkwy Ste 175
Durham, NC
27713

Telephone

+19192067900

Website

http://www.polarean.com/

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