01/07/2026
My thoughts on oral Wegovy (based on the limited info we have):
Small trial (307 patients)
74% GI side effect rate is EXTREME!
Must be taken daily and on an empty stomach. Cannot eat or drink anything for at least 30 minutes (probably longer is more ideal) afterward.
Weight loss mean 13.6% on HIGHEST dose (comparable to injectable that had 14.9% mean weight loss at highest dose). Study did not share weight loss results on the 1.5mg, 4mg, or 9mg dosing, which I posit suggests the weight loss on these doses is likely not very good.
Cost = $199/mo for 1.5mg and 4mg
$299/mo for 9mg and 25mg
VERDICT - unless you’re needle phobic, this medication does not provide any advantages over the injectable semaglutide, has slightly less weight loss, a much higher (I’d say extreme) GI side effect risk), and is at about the same price point.
Tirzepatide is still the best weight loss medication available.
Novo Nordisk's Wegovy pill is the first and only oral GLP-1 for weight loss in adults.