09/20/2025                                                                            
                                    
                                    
                                                                        
                                        Adaptogens and adrenal tonics support patients during times of ongoing stress and fatigue. Culminating in HPA axis dysfunction, common presentations include feelings of stress and overwhelm, mood changes, cognitive dysfunction/difficulty concentrating, fatigue including chronic fatigue/burnout, sleep disturbances, changes in appetite, weight gain/loss, and/or digestive symptoms.
Adaptogens increase non-specific resistance to stress, promoting adaptation and survival.[1] They have a normalizing effect on stress reactivity (reducing HPA hyperactivity and hypercortisolemia while also correcting HPA hypoactivity and hypocortisolemia).[2] They also improve physical and mental energy and support recovery from illness.
🌿 Rhodiola is an energizing adaptogen traditionally indicated for stress-related fatigue.[3]
🌿 Ashwagandha is a tonic and adaptogen for building vitality without stimulating, promoting restful sleep, and calming the stress response in tired, wired patients.[4]
🌿 Eleuthero is a restorative, non-stimulating adaptogen used to build energy and vitality following stress or illness. It is clinically shown to improve performance under stress, as well as stamina and performance in athletes.[4]
🌿 Licorice and Rehmannia are adrenal tonics which support the function of the adrenal cortex, particularly under prolonged stress conditions.[4]
[1] Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Annals NY Academy of Sciences. 2017 Aug;1401(1):49-64.
[2] Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity. Pharmaceuticals. 2010 Jan;3(1):188-224.
[3] Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsych Dis Treat. 2017;13:889.
[4] Bone K, Mills S. Principles and practice of phytotherapy: modern herbal medicine. 2nd ed. Edinburgh: Elsevier Health Sciences; 2013.