The Professional Clinical Lab., Magam

24/06/2025

🚨 WARN YOUR PATIENTS! 🚨

💊 More than 95% of so-called online pharmacies operate illegally and may be selling substandard and falsified drugs.

📰 In a recent newsletter article, Institute for Safe Medication Practices (ISMP) issued a call to action to inform patients about the dangers of purchasing counterfeit drugs online.

💉 The article shared a recent case where a patient presented to the emergency department with uncontrolled nausea and vomiting after injecting a dose of “semaglutide” that they purchased from an internet website.

🔗 For a copy of the article, which also provides ISMP’s safe practice recommendations and tips to pass on to patients, visit: https://hubs.la/Q03t8jMY0

17/05/2025

13/05/2025

Laboratory values

08/05/2025

(PBS) test, also known as a Blood Film or Peripheral Smear, is a laboratory procedure that involves examining a sample of blood under a microscope to assess the morphology (shape, size, and appearance) of blood cells. It's primarily used to diagnose and monitor blood-related disorders.

Purpose of the Test:

The PBS test helps in:
Identifying anemia types
Diagnosing infections
Detecting leukemias, lymphomas, and other hematological malignancies
Monitoring bone marrow function
Assessing platelet disorders

Specimen Collection:
Sample type: Venous blood
Anticoagulant: Typically EDTA (purple-top tube)

Procedure:
1. :
A drop of blood is placed on one end of a clean glass slide.
A second slide (spreader) is used at a 30–45° angle to spread the blood into a thin film.
The smear is allowed to air-dry completely.

2. :
The slide is stained using Romanowsky stains (most commonly Wright, Giemsa, or Leishman stain).
This helps in differentiating the cellular components.

3. :
The stained smear is examined under oil immersion (100× magnification).

A systematic review is done of:
(RBCs): Size (microcytic, macrocytic), shape (poikilocytosis), color (hypochromia), inclusions (Howell-Jolly bodies, Heinz bodies)

(WBCs): Total and differential count, morphology (blast cells, toxic granulation)

: Number, size, clumping

Normal Findings:

Component / Normal Appearance
. / Normocytic,normochromic, round,central pallor
. / Normal distribution of neutrophils,lymphocytes,monocytes,eosinophils,basophils
. / Scattered, small,purple granules

Abnormal Findings and Their Significance:

Abnormality. / Possible Indication
(RBC size variation) / Iron deficiency,anemia, thalassemia
(RBC shape variation) / Sickle cell anemia,spherocytosis
. / Hemolytic anemia
. / Liver disease,thalassemia
/ Leukemia
. / Megaloblastic anemia
. / mononucleosis
. / Pseudothrombocytopenia

Limitations:
Requires skilled interpretation.
May miss abnormalities if cells are not present in the thin area of the smear.

Clinical Utility:
Helps confirm or rule out findings from automated hematology analyzers.
Essential in the evaluation of unexplained cytopenias, fever of unknown origin, and suspected hematologic malignancies.
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04/05/2025

03/05/2025