10/08/2025
                                            🔬 2025 Nobel Prize in Medicine Goes to the Immune System’s “Brake Pedal”
This year’s award in Physiology or Medicine recognizes the seminal work on regulatory T cells (T-regs) — the immune system’s crucial restraint system. 
The laureates — Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi — uncovered how immune cells keep self-reactive responses from spiraling into autoimmunity, and identified the key transcription factor FOXP3 that defines and regulates T-regs. 
🧠 Why This Matters to Us (as Providers / Immunologists / Allergists)
T-regs are central to peripheral immune tolerance — the mechanism preventing our immune system from attacking healthy tissue. 
Dysregulation of T-regs (or FOXP3 mutations) causes severe autoimmune conditions. 
Their discovery opens new therapeutic windows: modulating T-reg activity for autoimmune disease, transplantation, cancer immunotherapy, and more