03/25/2026
Does Hyperbaric Oxygen Therapy (HBOT) increase stem cell production?
We have known for well over 20 years that HBOT actually stimulates, mobilizes, and increases circulating stem cells.
The overwhelming majority of that research has been done at higher pressures, 2.0 atmospheres or above.
A question I get all the time is "Will mild HBOT actually increase stem cell mobilization?"
In 2023, Kent McLaughlin at the University of Wisconsin did a study using mild HBOT. Specifically, he used a soft chamber with air only (no supplemental oxygen).
So, this was a 1.3 ATA, 21% oxygen, for a ten session protocol.
This study also tried to mimic one of the higher pressure studies as closely as it could.
Over the course of these ten sessions, they found between a 2.5-3 times increase in mobilized stem cells.
At some of the highest pressures, we typically go 2.0 to 2.4 atmospheres on 100% oxygen. We should be able to get consistent findings of around an eight fold increase in the stem cell production at those pressures.
Then, at the most mild end of that same spectrum, 1.3 ATA on air only, we can expect to find somewhere between a 2.5-3 fold increase in mobilized stem cells.
The next question might be, "what about 1.5 or 1.75 on air or on oxygen?" The answer is we don't know yet.
However, knowing what we usually get at 1.3 ATA and then 2.0 ATA, we can assume that these different pressures and different percentages of oxygen are going to end up filling in somewhere in between those two goalposts.
What we know is that all of the pressures increase stem cells and therefore can be used as part of a strategy for healing and regeneration.