05/29/2020
I have been seeing many posts and advertisements about COVID-19 antibody testing recently. Some of these posts have incomplete information, while others are downright misleading, so I decided to weigh in on the subject.
First of all, there are 2 types of COVID-19 antibody tests, IgM and IgG. IgM antibodies appear first, a few days after the infection is acquired, then disappear over the next couple of weeks. IgG antibodies appear about 2 weeks into the infection but last much longer. IgG antibody testing is what most people are interested in right now, since it indicates a previous COVID-19 infection.
IgG tests that are run on sophisticated instruments in large laboratories appear to be very accurate. This antibody test is what most clinics are now conducting, including mine. Blood samples are sent to either a hospital or other large laboratory, and results are typically back within a day or two. There are other test kits that are used in some clinics with results in a few minutes, but this type of test is much less reliable than the ones sent to labs with complex instruments.
The test with which I am most familiar is the Abbott brand, since this test is what my lab uses. The sensitivity of this test is virtually 100% as long as it has been 3 weeks or more since infection occurred. Its specificity is approximately 99.8%, which means that 99.8% of patients who have not had COVID-19 will test negative. This is a highly satisfactory number, but if tens of thousands of patients are tested, these false positives will add up. Nevertheless, we know this test is of excellent quality to identify if IgG antibodies are present. What is unknown is whether having IgG antibodies signifies having immunity from future COVID-19 infections, and if you do have immunity, how long it lasts. We’ve only known this virus existed for about 6 months, so finding these answers will take time. A positive IgG antibody test does mean that you may be able to donate plasma to potentially help those infected with the COVID-19 virus.
So, should you have the IgG antibody test done? It’s not essential that anyone get tested right now, but there’s also no harm in having it done if you want it either. Here are some scenarios to think about.
-If you had a respiratory infection this past winter, weren’t tested for COVID-19, and are interested in donating plasma if you’re eligible, it is likely worthwhile to have the IgG antibody test.
-If you were around people who tested positive for COVID-19 (in your workplace, for example), but you were never tested, and you just want to know if you had this virus, it is less worthwhile to have the IgG antibody test, but worth considering if you really want to know if you were previously infected..
-If you haven’t been sick and are just curious, it is probably not worth having an IgG antibody test, but it won’t hurt anything if you want to have it anyway. My observations and research lead me to believe that no more than 3-5% of Mississippians have antibodies at this time.
My clinic charges $50 for the test plus your usual out of pocket cost for an office visit. We do require an office visit so that we can explain what the test means and what it doesn’t. I think this pricing and requirement of a visit is consistent across most clinics. Insurance may cover the cost of the test, but the coverage varies from one insurance plan to another. Also, I would expect people to be tested more than once as the months go by, and if an insurance company pays for the test at all, I would not expect them to cover it repeatedly, so plan to pay up front for this IgG antibody test for the foreseeable future. If you are interested in testing at my clinic, call 601-200-4321