07/20/2025
Dry eyes? (Ladies)
🧠 Hormones and Dry Eyes? 👁️
New research brings hope to an often overlooked symptom of perimenopause: severe dry eye disease.
🔬 In this randomized controlled trial, perimenopausal women with severe dry eye symptoms were treated with:
✔️ Estrogen replacement therapy (ERT)
✔️ Autologous serum eye drops (AS)
✔️ Both ERT + AS
💊 The treatment protocol:
• 2 mg of nilestriol taken orally every 15 days
• 2 mg of progesterone daily added for 15 days after the second nilestriol dose
• Autologous serum applied directly to the eyes throughout the treatment cycle
📈 After 30 days:
✅ Estradiol (E2) levels increased
✅ FSH and LH levels decreased
✅ Tear breakup time and Schirmer scores improved significantly
✅ Inflammatory markers (VEGF, IL-1β, TNF-α) dropped most in the combo group (ERT + AS)
✅ Corneal staining decreased
✅ Kupperman scores (a menopause symptom scale) fell steadily
This is one of the few studies focused specifically on perimenopausal patients, and it’s exciting to see new, high-quality research in such an underserved area of women’s health. Hormonal changes during this transition impact far more than just hot flashes.
➡️ If you’re struggling with dry, gritty, burning eyes and nothing seems to help, hormones may be part of the picture. You deserve a clinician who understands that.
Reference:
Li T, Tang J, Wang X, et al. Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women. Sci Rep. 2025;15(1):26096. doi:10.1038/s41598-025-03638-9