08/28/2024
I was contemplating what to do with all of the sweet potato vines over running my garden, herb beds and up the fence and out into the field. Turns out they're exactly what my body needs- highly loaded with anticancer compounds. Nice, - thank you!
Direct from pub med https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038024/
"4.1. Anti-Cancer Activity
Leaves of sweet potato have been recognized as a potent anti-cancer food source against various cancer cells, including HCT-116 colon cancer [103], HeLa cancer [103], MCF-7 breast cancer [15], prostate cancer [16], colorectal cancer [104], and lung cancer [102] cells due to high content of anthocyanins [44,45], and polyphenols [7]. Methanol extracts of SPL inhibit proliferation of all human prostate cancer cells (PC-3, C4-2B, C4-2, DU145, and LNCaP) with IC50 values of 145–315 μg/mL due to modulations of cell cycle, inductions of apoptosis, and reductions of clonogenic survival [79]. The anti-prostate cancer activity of SPL is attributed to the presence of 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid, quinic acid, isochlorogenic acids, caffeic acid, and ester chlorogenic acid [16]. Chen et al. [42] showed that polyphenols in purple SPL depressed proliferation, migration, and tube formation of vascular endothelial growth factor-treated human umbilical vascular endothelial cells (HUVECs). Chlorogenic acid was reported as a strong and selective inhibitor of matrix metalloproteinase-2 [42] and matrix metalloproteinase-9 [105], which are angiogenic enzymes responsible for tumor metastasis and invasion, so that it can demonstrate several desirable anti-carcinogenic properties including inhibitory activity against A549 human lung cancer cells [102]. Caffeoylquinic acid derivatives also have potential for cancer prevention through apoptosis induction by increasing caspase-3 activity and expression of c-Jun (apoptosis-related gene) [7]. Among these compounds, 3,4,5-tri-O-caffeoylquinic acid effectively inhibits the development of human colon cancer DLD-1 cells, promyelocytic leukemia HL-60 cells, and stomach Kato III cancer cells, whereas caffeic acid demonstrates higher inhibitory activity against HL-60 cells than other di- and tri-O-caffeoylquinic acids [7]. Recently, a 16-amino-acid peptide, named the peptide Ipomoea batatas anti-cancer peptide (IbACP) from SPL, showed the inhibition of pancreatic cancer line [68]. Several studies have also been performed to evaluate the in vivo anti-cancer activity of SPL [6,16]. Gundala et al. [16] reported that the daily consumption of polyphenol-rich SPL extract (400 mg/kg) inhibited the growth and induced the apoptosis in both human prostate cancer cell and in vivo prostate cancer xenograft models. Similarly, the consumption of Okinawan SPL extract (200 ppm and 1000 ppm) for 12 weeks potentially inhibited the progression and development of neoplasms in mouse colon carcinogenesis model [6]."
Sweet potato (Ipomoea batatas) is one of the most important food crops worldwide and its leaves provide a dietary source of nutrients and various bioactive compounds. These constituents of sweet potato leaves (SPL) vary among varieties and play important ...