05/19/2026
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An increasing amount of findings has demonstrated that microglial activation and neuroinflammation play a crucial role in the pathogenesis of neurodegenerative disorders. Recent researches revealed that there are many compounds isolated from natural plants that can delay the neuronal damaged and degenerative progression by inhibiting microglial activation, so they have attracted considerable attention as pharmacological intervention against neurodegenerative discords with neuroinflammatory condition. As illustrated in the summary diagram (Figure 1), these literatures provide the evidences that herbal compounds can protect neuronal damage characterized by neuroinflammatory and oxidative stress condition and they accomplish their role by suppressing microglial activation and proinflammatory and neurotoxic mediator expression via blocking the related signaling pathway in activated microglia. Moreover, the natural products and compounds are inexpensive, easily accessible, and safe. Therefore, they can be widely observed in laboratory researches. If these activities of herbal compounds that are found in laboratory research are beneficial to delaying the development of neurodegenerative disorders, then large and well-designed studies in clinic are required to confirm whether or not their activity is also possible in humans. Further study of the pharmacological mechanisms of natural herbal compounds on the inhibition of microglial activation and neuroinflammation could not only benefit the discovery of effective neuroprotective components but also help researchers to learn more about the pathological mechanisms of neurodegenerative disorders.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5932434/
Since microglia possess both neuroprotective and neurotoxic potential, they play a crucial role in the central nervous system (CNS). Excessive microglial activation induces inflammation-mediated neuronal damage and degeneration. At present, numerous ...