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The Researcher OG, Santa Barbara, CA (2025)

10/31/2025

Autism isn’t something that needs fixing - it’s a neurological variation that deserves understanding and support, not correction. The idea that cannabis could or should “fix” autism is misguided and often offensive to those who live it every day. Most autistic people don’t want to be “cured” - they want relief from the pain, anxiety, sensory overload, and inflammation that can come with living in a world not designed for their brains.

The parents who understand this know that healing doesn’t mean changing who someone is; it means helping their body and mind find balance.

Cannabinoids do not change autism - they modulate the systems that underlie its challenges. The Master Regulator - the Endocannabinoid System - manages communication between neurons, immune cells, and hormones. Studies like “Deficiency of the Endocannabinoid System in Autism Spectrum Disorder: Emerging Evidence and Therapeutic Implications” (Molecular Autism, Aran et al., 2021) show that people on the spectrum often have reduced endocannabinoid tone, meaning the system that maintains emotional and sensory regulation isn’t firing correctly.

When cannabinoids like CBD, CBGA, or CBG interact with those receptors, they help restore balance without altering personality or cognition.

Cannabinoids calm hyperactive neural pathways, regulate glutamate and GABA flow, and reduce neuroinflammation that can drive seizures or mood instability. They also improve sleep architecture, support mitochondrial function, and stabilize sensory processing by restoring receptor sensitivity in brain regions tied to emotion and focus. CBGA, in particular, promotes gentle endocannabinoid activity without intoxicating effects, helping the system reconnect naturally.

Cannabis doesn’t fix autism because autism isn’t broken - what it does is help the body function with less friction. By activating the Master Regulator, cannabinoids allow individuals on the spectrum to experience calmer transitions, better focus, reduced pain, and improved overall homeostasis while remaining entirely themselves.

Actual progress in autism care begins not with the goal of change but with the intention of balance.

-Mike Robinson, The Researcher OG

10/31/2025

Psoriasis is more than a skin condition - it is a chronic immune disorder driven by inflammation, oxidative stress, and a breakdown in cellular communication. The Master Regulator - the Endocannabinoid System - governs that very communication across skin, immune, and nervous tissues. When its tone is low or receptors are desensitized, immune cells misfire, keratinocytes overproduce, and skin cells stack up faster than the body can shed them.

A 2007 study titled “Cannabinoids Inhibit Keratinocyte Proliferation Through a Non-CB1/CB2 Mechanism” (Journal of Dermatological Science, Wilkinson and Williamson, 2007) demonstrated that cannabinoids directly slow down abnormal skin cell growth and reduce inflammation in psoriatic tissue.

Topically applied cannabinoids like CBD, CBG, and CBGA interact with CB1, CB2, and TRPV receptors in the epidermis and dermis. These receptors regulate inflammation, oxidative stress, and keratinocyte turnover. CBD in particular suppresses inflammatory cytokines such as IL-6 and TNF-α while stabilizing mast cells, which often drive itching and redness.

CBGA’s acidic structure acts as a biosignal amplifier, enhancing lipid metabolism and strengthening the skin’s barrier integrity. Together, they calm the immune storm on the surface, allowing the skin to breathe, hydrate, and repair.

When cannabinoids are ingested, they work systemically through the Master Regulator to control immune signaling at its source. The ECS communicates with the thymus, spleen, and bone marrow to regulate T-cell activation and inflammatory cascades that fuel psoriasis from within. Ingested cannabinoids reduce cytokine overproduction and oxidative stress, improving not just the skin but the entire immune landscape.

The dual approach of topical and internal cannabinoid use creates a two-way correction - surface inflammation is soothed while systemic immune activity is balanced. This synergy allows the body to repair from both ends of the network, addressing the actual cause rather than the symptom.

Psoriasis, at its root, is a failure of biological communication, and cannabinoids restore that dialogue through The Master Regulator, helping skin return to calm, clear, and functional balance.

-Mike Robinson, The Researcher OG

10/31/2025

Arthritis, whether rheumatoid, osteo, or psoriatic, is not just joint pain - it is chronic immune dysregulation fueled by inflammation, oxidation, and nervous system imbalance. The Master Regulator - the Endocannabinoid System - controls the communication between these systems, determining how the body perceives pain, handles inflammation, and rebuilds tissue.

A 2008 study titled “Cannabinoid Receptors and the Regulation of Bone Mass” (British Journal of Pharmacology, Ofek et al., 2008) showed that CB1 and CB2 receptors are deeply involved in joint and bone homeostasis, influencing both inflammatory cytokine release and bone regeneration.

When cannabis is ingested rather than smoked, its cannabinoids move through the digestive system and liver before entering circulation. This process produces active metabolites that persist longer in the body and reach deeper tissues, including inflamed joints. THC and CBD together reduce pain and swelling by acting on CB2 receptors within the immune cells surrounding the joints, while also inhibiting the production of TNF-α and IL-1β - the same cytokines responsible for joint destruction in rheumatoid arthritis.

CBGA and CBG further strengthen this effect through their anti-inflammatory and antioxidant actions. They protect cartilage and connective tissue from oxidative stress while promoting mitochondrial repair in joint cells. These cannabinoids also modulate the vanilloid receptor (TRPV1), which is responsible for pain perception, meaning that ingestion not only calms inflammation but also reprograms how the nervous system interprets discomfort.

Through the Master Regulator, cannabinoids restore joint homeostasis by calming immune overactivity, improving blood flow, and helping cartilage cells rebuild faster than they are damaged. Unlike pharmaceuticals that block inflammation chemically, cannabinoids guide the body back toward balance biologically.

In essence, ingesting cannabis for arthritis doesn’t just mute the pain - it tunes the system. By feeding the Master Regulator, it lowers inflammation at its origin, relieves pain through receptor modulation, and supports long-term restoration of joint integrity and mobility.

-Mike Robinson, The Researcher OG

10/30/2025

The skin is one of the body’s most active sites of endocannabinoid signaling, and its health depends heavily on The Master Regulator - the Endocannabinoid System - maintaining balance between oil production, immune activity, and cell turnover. When that balance is lost, inflammation rises, sebum production spikes, and acne or chronic skin disorders can emerge.

A pivotal 2014 study titled “Cannabidiol Exerts Sebostatic and Anti-inflammatory Effects on Human Sebocytes” (Journal of Clinical Investigation, Oláh et al., 2014) revealed that cannabinoids, particularly CBD, can normalize skin function by acting directly on sebaceous gland cells and inflammatory pathways.

CBD works by activating and modulating TRPV1 and adenosine receptors, reducing the excessive lipid synthesis that clogs pores and feeds bacterial growth. It also downregulates inflammatory cytokines like TNF-α, IL-1β, and IL-6, all key drivers of acne and eczema flare-ups. Through these actions, CBD helps restore the natural lipid rhythm that keeps skin hydrated without overproduction. CBG and CBGA extend this benefit by acting as antibacterial and antioxidant agents, protecting against oxidative stress that accelerates skin aging and damage.

The Master Regulator’s receptors - CB1 and CB2 - are distributed throughout the epidermis, hair follicles, and sebaceous glands. These receptors control the delicate balance between keratinocyte proliferation and immune response. When cannabinoids restore endocannabinoid tone, they calm overactive immune cells, repair the skin barrier, and enhance oxygen and nutrient flow.

Even deeper, ECS modulation influences mitochondrial activity in skin cells, supporting faster healing and collagen renewal. That’s why topical or systemic cannabinoids can help with psoriasis, dermatitis, acne, and even wound recovery.

In short, cannabinoids help the skin do what it was designed to do - protect, breathe, and renew. By balancing The Master Regulator at the surface and within, they soothe inflammation, regulate oil, and transform skin from reactive to resilient, proving once again that true healing begins with internal balance.

-Mike Robinson, The Researcher OG

10/30/2025

In the late 1970s and early 1980s, a small group of Americans became part of a historic federal program known as the Compassionate Investigational New Drug Program. These individuals, diagnosed with severe conditions like glaucoma and multiple sclerosis, were legally supplied with cannabis ci******es by the U.S. government.

One of the most well-documented participants, Robert Randall, suffered from advanced glaucoma that resisted every pharmaceutical available at the time. His landmark 1976 court case, United States v. Randall, forced the government to acknowledge that cannabis reduced his intraocular pressure better than any drug ever tested.

Randall wasn’t seeking to get high - he was seeking to see. The cannabis he received from the government was pre-rolled by the National Institute on Drug Abuse and shipped monthly in metal tins. Each tin contained 300 joints made from low-grade plant material grown at the University of Mississippi, yet despite the quality, it worked. His intraocular pressure stabilized, his vision improved, and his dependency on pharmaceuticals vanished.

To this day, no synthetic or pharmaceutical compound fully replicates the mechanism through which cannabinoids relieve ocular pressure. Cannabis reduces intraocular pressure by activating CB1 receptors in ocular tissues, improving fluid drainage and blood flow through endocannabinoid modulation.

A 2001 study titled “The Endocannabinoid System and the Control of Intraocular Pressure” (Brain Research Reviews, Pinar-Sueiro et al., 2001) confirmed that the ECS directly governs ocular fluid balance.
The irony remains powerful: the U.S. government acknowledged medical benefit decades before allowing public access, while the very patients they helped became living proof of something bigger.

They weren’t chasing euphoria - they were chasing equilibrium. What they experienced was the Master Regulator doing its job, restoring balance where modern medicine still struggles to reach. Cannabinoids gave them not escape, but control - the kind of control that only nature’s own chemistry could provide.

-Mike Robinson, The Researcher OG

10/30/2025

Anxiety is one of the most evident signs of an overworked and underbalanced nervous system, and The Master Regulator - the Endocannabinoid System - is central to restoring calm. The ECS maintains equilibrium between the brain’s excitatory and inhibitory signals, shaping how we respond to stress, fear, and uncertainty.

When endocannabinoid tone drops, the amygdala and prefrontal cortex become overactive, flooding the body with cortisol and adrenaline. A 2011 study titled “Cannabidiol Reduces Anxiety in Social Anxiety Disorder” (Neuropsychopharmacology, Bergamaschi et al., 2011) confirmed that activating ECS pathways through phytocannabinoids can significantly reduce both subjective anxiety and measurable stress markers in humans.

Cannabinoids achieve this by modulating receptor activity across multiple networks. CBD increases anandamide levels by inhibiting FAAH, the enzyme that breaks it down, creating a sustained calming effect. CBG and CBGA enhance GABAergic signaling, allowing the brain’s inhibitory circuits to quiet excessive neural firing.

Low doses of THC activate CB1 receptors in the amygdala and hippocampus, helping the brain reinterpret fear signals and regain a sense of safety. Together, these cannabinoids regulate neurotransmitters like serotonin, dopamine, and glutamate, stabilizing emotional tone and perception.

Within The Master Regulator, this effect extends beyond the brain. ECS receptors in the gut and immune system reduce inflammation-driven anxiety by lowering cytokine activity and restoring vagal nerve communication. As inflammation drops, serotonin synthesis in the gut increases, creating a bottom-up calming effect that complements the top-down neural response.

In essence, cannabinoids don’t suppress emotion - they rebalance the circuitry that processes it. By strengthening endocannabinoid tone, they help the brain shift out of survival mode, calm the body’s alarm system, and reestablish emotional homeostasis. Through ECS modulation, anxiety transforms from an unmanageable wave into a message the body can process, resolve, and release naturally.

-Mike Robinson, The Researcher OG

10/29/2025

Anorexia nervosa is not only a psychological disorder but also a deep disruption in metabolic and endocannabinoid signaling. The Master Regulator - the Endocannabinoid System - controls hunger, satiety, reward, and emotional balance through endocannabinoids like anandamide and 2-AG acting in the hypothalamus, limbic system, and gut.

A landmark study titled “Altered Endocannabinoid Activity in Anorexia Nervosa and Bulimia Nervosa” (Biological Psychiatry, Monteleone et al., 2005) showed that patients with anorexia have significantly lower circulating anandamide levels, along with reduced CB1 receptor availability in key brain regions governing appetite and mood.

This disruption disconnects the physiological sensation of hunger from emotional reward, making food intake feel unnatural or distressing.
Cannabinoids can help restore that missing communication.

By activating CB1 receptors, compounds like THC and CBG stimulate appetite and enhance the release of ghrelin - the hunger hormone - while also calming hyperactive stress responses that maintain food avoidance.

CBD and CBGA act as modulators, balancing serotonergic and dopaminergic pathways, which eases anxiety and obsessive thoughts tied to eating. These phytochemicals collectively rebalance neurotransmitter flow through The Master Regulator, allowing both appetite and emotional control to return in synchrony.

Beyond feeding behavior, cannabinoids influence neuroinflammation, mitochondrial output, and energy balance, all of which are profoundly altered in anorexia. ECS activation supports homeostasis in the gut-brain axis, improving nutrient signaling, digestion, and mood.

When endocannabinoid tone rises, leptin and insulin sensitivity normalize, allowing the body to respond appropriately to nutritional intake rather than rejecting it.

In short, anorexia nervosa represents a collapse in the Master Regulator’s feedback loop between hunger and emotion. Cannabinoids don’t just stimulate appetite - they restore the underlying neural dialogue between body and mind, giving patients back the internal balance required to heal both physiologically and emotionally.

-Mike Robinson, The Researcher OG

10/29/2025

The relationship between cannabinoids and testosterone is guided by The Master Regulator - the Endocannabinoid System - which controls nearly every hormonal rhythm in the body. Declining testosterone is often seen as a symptom of aging, but in truth, it reflects disrupted ECS tone. When endocannabinoids like anandamide and 2-AG are low, receptor communication between the brain, adrenals, and te**es weakens.

This slows luteinizing hormone release and reduces Leydig cell activity - the cells responsible for testosterone synthesis. A 2013 study titled “The Endocannabinoid System and the Regulation of Male Reproductive Functions” (Cacciola et al., Frontiers in Endocrinology, 2013) demonstrated that cannabinoid signaling tightly regulates both s***m function and hormone production through CB1 receptors in the hypothalamic-pituitary-gonadal axis.

Certain cannabinoids restore this rhythm by rebalancing receptor tone and stimulating endocannabinoid synthesis. CBGA, for example, helps restore natural lipid signaling that drives steroidogenesis, while CBD acts as a mild modulator of cortisol, reducing stress-induced interference that suppresses testosterone. CBGa and THCv both enhance metabolic drive and support nitric oxide release, improving circulation to endocrine tissues.

When endocannabinoid tone is low, testosterone decline often accelerates because the hypothalamus loses its feedback control over gonadotropin-releasing hormone. Cannabinoids buffer this imbalance by reducing neuroinflammation, promoting mitochondrial function, and restoring homeostatic signaling across neural and endocrine tissues.

This explains why consistent ECS activation - through plant cannabinoids, exercise, and proper diet - slows the hormonal aging process.

In short, testosterone decline is not just an endocrine issue - it’s an endocannabinoid imbalance. By restoring ECS tone with balanced cannabinoid intake, the body naturally recalibrates its hormonal output, sustaining vitality, strength, and mood as it was designed to do.

ECS balance is critical.

-Mike Robinson, The Researcher OG

10/29/2025

CBGA initiates what can be called the neuro-lipid activation phase - the process that sets the brain and body’s communication systems in motion each morning. As the acidic precursor to all cannabinoids, CBGA acts like a biochemical starter switch. When taken early in the day, it stimulates the endocannabinoid network - The Master Regulator - to begin producing and mobilizing its own lipid messengers, primarily anandamide and 2-AG. These compounds are the body’s natural mood, energy, and balance modulators.

CBGA enhances the sensitivity and density of cannabinoid and related receptors, allowing endocannabinoids to bind more effectively. This activity synchronizes neuro-lipid signaling with mitochondrial output, creating a steady release of cellular energy and improved neurotransmitter flow. In the brain, it supports lipid-based synaptic remodeling, which sharpens focus, lifts cognitive function, and sets a calm but alert tone for the day.

On a systemic level, CBGA also influences AMPK and PPAR pathways, balancing fat metabolism and inflammation at their root. By converting stored lipids into usable cellular fuel, it helps transition the body from a state of rest and repair into one of movement and productivity.

In short, CBGA doesn’t just wake the mind - it aligns the body’s lipid and hormonal communication lines, launching the neuro-lipid activation phase that fuels focus, endurance, and emotional stability through The Master Regulator. -Mike Robinson, The Researcher OG

10/28/2025

CB1 receptors are not just in the brain – they are woven throughout the human body, acting as part of a vast internal communication system that keeps us balanced and responsive. These receptors live in cell membranes, built into the lipid layers that surround and protect each cell.
When cannabinoids interact with them, they do not just alter mood or perception; they influence how cells talk to one another across entire systems. The brain may host the highest concentration of CB1 receptors, but they also line the gut, reproductive organs, liver, skin, heart, and even the immune system. They regulate everything from neurotransmitter release to metabolic rhythm and stress response.

CB1 receptors are a key arm of The Master Regulator – the Endocannabinoid System – which manages homeostasis at the cellular level. Each receptor is a molecular gatekeeper that responds to endocannabinoids like anandamide and 2-AG, as well as plant-based cannabinoids such as THC, CBG, and CBGa. When these compounds bind, they trigger a cascade of signals that alter cell behavior – calming neurons, reducing inflammation, improving energy flow, or modulating hormone output. It is precision biology, not intoxication.
What makes CB1 unique is its range. It can inhibit overactive signals, stabilize ion flow, and fine-tune communication between brain and body. When ECS tone is healthy, CB1 activity helps the nervous system relax, digestion flow smoothly, pain perception stay normal, and emotional balance hold steady. When ECS tone drops, we see anxiety, insomnia, inflammation, and a loss of regulation across multiple systems.

Modern stress, poor diet, and excessive THC can wear these receptors down. Cannabinoids like CBGa help restore tone by promoting receptor repopulation and improving cell signaling. Supporting CB1 health is not about chasing a high – it is about feeding the network that connects every cell, organ, and nerve. CB1 receptors remind us that balance does not start in the mind – it starts in the cell.
-Mike Robinson, ResearcherOG

10/28/2025

The average 2025 diet is a CO₂ factory. Ultra-processed foods loaded with refined sugars, excessive omega-6 seed oils, artificial additives, and empty carbs burn hot and dirty inside the body. As this low-quality fuel is metabolized, it produces excess carbon dioxide and metabolic waste. When paired with sedentary living, shallow breathing, stress, poor sleep, and dehydration, CO₂ builds faster than the body can expel it.

This internal environment becomes acidic, oxygen-poor, and overstimulated – and that directly weakens The Master Regulator, the Endocannabinoid System.

The ECS depends on lipid-based receptor integrity, proper oxygenation, and efficient cellular respiration. But when the body is overwhelmed with inflammatory foods, mitochondrial efficiency drops. Cells shift toward near-anaerobic metabolism, increasing CO₂ buildup while lowering endogenous cannabinoid levels, such as anandamide and 2-AG.

Chronic inflammation impairs ECS signaling, while cortisol from chronic stress further disrupts it. In this state, no amount of CBD, CBGa, THC, or terpene-infused extract can perform at full potential because the internal communication grid is congested.

People wonder why they still feel anxious, bloated, inflamed, or in pain despite consuming cannabinoids daily. The truth is simple – phytocannabinoids cannot override a carbon-loaded, poorly oxygenated, nutritionally deprived system. Receptors become less responsive when cellular membranes are built from damaged seed oils instead of omega-3s and healthy fats. Endocannabinoid tone collapses when cortisol is constant and movement is nonexistent.

Exercise restores CO₂ balance by improving oxygen delivery, increasing mitochondrial efficiency, enhancing lymphatic flow, and stimulating natural endocannabinoid release. A nutrient-rich diet filled with whole foods, quality fats, phytoactives, hydration, minerals, and fiber rebuilds the ECS environment. Better breathing, better movement, better fuel – better signaling.

Cannabinoid extracts are amplifiers, not magic wands. They work best in a body that breathes deeply, eats intentionally, moves daily, and gives The Master Regulator a clean stage to perform. Without lifestyle alignment, people aren’t treating dysfunction – they’re just decorating it.

-Mike Robinson, The Researcher OG

10/28/2025

Hypertension is not just “high blood pressure” – it is a chronic state of vascular tension driven by inflammation, stress hormones, endothelial dysfunction, and nervous system overactivity. When the body lives in a state of constant alert, the sympathetic nervous system stays locked in fight-or-flight mode, blood vessels constrict, and the heart is forced to pump harder. Over time, immune cells release inflammatory cytokines like IL-6 and TNF-α, which damage the endothelium lining blood vessels, reducing nitric oxide availability and increasing arterial stiffness.

Deep underneath this imbalance is The Master Regulator – the Endocannabinoid System – which helps maintain vascular tone, calm inflammatory responses, and balance nervous system signaling between stress and relaxation. When the ECS is dysregulated, blood pressure rises more easily, vessels lose their flexibility, and inflammation becomes a constant pressure amplifier.

Cannabinoids help by supporting ECS function and targeting multiple mechanisms involved in hypertension. CBD has been studied for its ability to reduce vascular resistance and improve endothelial function, partly by increasing nitric oxide availability and reducing oxidative stress within blood vessels.

THC in low, carefully managed doses can activate CB1 receptors to reduce sympathetic nervous system overdrive, easing stress-induced surges in blood pressure. Meanwhile, CB2 receptor activation through cannabinoids like CBD, CBG, and CBGa helps reduce inflammatory damage to vascular tissues, improving long-term arterial health.

A 2017 study titled “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study” documented CBD’s ability to lower resting systolic blood pressure and reduce blood pressure increases induced by stress. This study confirms that cannabinoids modulate cardiovascular responses via ECS pathways that regulate stress, vascular relaxation, and immune balance.

CBGa may play a role in upstream ECS support, helping restore overall endocannabinoid tone and improving resilience against chronic stressors that elevate blood pressure. By supporting the natural function of anandamide and 2-AG, cannabinoids help the ECS recalibrate vascular control rather than forcing artificial suppression of symptoms.

Hypertension is a sign that the body is living under pressure without proper regulation. The ECS, when supported by cannabinoids, helps reduce inflammatory tension, calm stress-driven vasoconstriction, and restore vascular rhythm. Instead of just lowering numbers, cannabinoids help address the imbalance behind the rise, giving the cardiovascular system the chance to exhale.

-Mike Robinson, The Researcher OG

The Researcher OG

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