
09/08/2025
Pain is complex, and cannabis brings more than one way to manage it. The three main players most people hear about - THC, CBD, and CBG - each take a different path in how they ease discomfort.
THC interacts strongly with CB1 receptors in the brain and spinal cord. This is where pain signals are processed. By binding to these receptors, THC changes how pain is perceived and also reduces the emotional stress tied to pain. It can make the signal less sharp and the experience less overwhelming.
CBD works differently. It does not bind tightly to CB1 or CB2 receptors but instead influences other systems like serotonin, TRPV1, and inflammatory pathways. This makes CBD useful for inflammatory and neuropathic pain, where calming the overactive nerves and immune cells matters most. CBD also helps modulate THC, softening its psychoactive punch while keeping the pain relief.
CBG, often called the “mother cannabinoid,” targets alpha-2 adrenergic receptors and TRP channels, giving it a unique analgesic profile. It reduces inflammatory pain, helps with muscle relaxation, and may even influence how endocannabinoids like anandamide last longer in the system. CBG is less studied than THC or CBD, but its early data shows promise for gut pain, nerve pain, and conditions like arthritis.
One study that highlights this science is “Cannabinoids and Pain: New Insights From Old Molecules” (2018), which reviewed how different cannabinoids interact with both the ECS and other pain pathways to provide relief.
Together, THC, CBD, and CBG cover a wide spectrum - from altering brain perception of pain, to calming inflammation, to protecting nerves. This is why whole-plant approaches often work best, letting each cannabinoid play its own role in the orchestra of pain relief.
-Mike Robinson