02/27/2026
Lung cancer in people who have never smoked now represents a significant and growing share of global cases.
A recent review from researchers at UCL (University College London) calls for increased research, screening, and risk-based assessment for lung cancer in never-smokers. As smoking rates decline, this group accounts for a larger proportion of diagnoses, yet screening programs still focus primarily on smoking history.
Key concerns include:
• Later diagnosis due to lack of screening pathways
• Distinct biology compared to smoking-related lung cancer
• Emerging risk factors such as genetics, air pollution, radon, and clonal hematopoiesis
• Different treatment responses, including lower effectiveness of some immunotherapies
Researchers argue that lung cancer in never-smokers should be treated as a distinct clinical category, with dedicated study and updated screening strategies.
As our understanding of respiratory disease evolves, early detection and risk-based screening become increasingly important.
Read more from UCL 👉 https://bit.ly/4rlhasd