Dr. Todd Maderis

Dr. Todd Maderis Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from Dr. Todd Maderis, Doctor, Greenbrae, CA.

I specialize in treating Lyme disease and tickborne infections, mold-related illness, autoimmune conditions, chronic viral infections, and conditions with complex chronic illnesses - mast cell activation disorder and chronic fatigue syndrome.

The pathophysiology of mold-related illness is from the toxic effect of mycotoxins produced by molds. Exposure to mycoto...
09/28/2024

The pathophysiology of mold-related illness is from the toxic effect of mycotoxins produced by molds. Exposure to mycotoxins can cause inflammation, immune system dysregulation, and tissue damage via oxidative stress. Researchers in this new study set out to determine if the herbal medicine milk thistle (silymarin) would protect against these harmful mechanisms in an animal model (young rabbits).

The rabbits were divided into three groups. All groups were fed a diet infected with aflatoxin B1, and two of the groups received silymarin in different doses. The groups with silymarin had improved growth performance, red blood cell count, and antioxidant capacity. Interestingly, the groups that received silymarin also had better intestinal villi (nutrient absorption surface area). Liver enzymes and oxidative stress markers were also reduced in the groups treated with milk thistle.

Overall, supplementing with milk thistle reduced the adverse effects of exposure to aflatoxin. Therefore, this easily accessible herbal medicine should be considered in treating mold-related illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408635/
https://drtoddmaderis.com/chronic-inflammatory-response-syndrome)


Hypermobility has been found in 30%-57% of patients with chronic fatigue syndrome (ME/CFS), POTS, fibromyalgia, and Long...
09/27/2024

Hypermobility has been found in 30%-57% of patients with chronic fatigue syndrome (ME/CFS), POTS, fibromyalgia, and Long COVID compared to 10%-20% of the general population. Hypermobile Ehlers-Danlos syndrome (hEDS) is the most common joint hypermobility condition, accounting for 90% of all hypermobility spectrum disorders physicians encounter. Besides musculoskeletal symptoms, hEDS is associated with anxiety disorders, chronic pain, fatigue, orthostatic intolerance, functional gastrointestinal disorders, and pelvic and bladder dysfunction.

Mast cell activation syndrome (MCAS) in Long COVID and ME/CFS (up to 80% of ME/CFS is post-infection) can result in inflammation and damage connective tissue, contributing to hypermobility. Two physicians from the Mayo Clinic recently published this thorough article outlining the effects infection-associated chronic illness may play in the development of hypermobility. “Given the large numbers of people affected by long COVID, it is critical to screen for hypermobility and other related conditions and enroll patients into multidisciplinary treatment teams to provide individualized treatment plans to maximize function and minimize symptoms.”

Did you develop a hypermobility spectrum disorder following an infection? Comment below.

Click the link in the bio for the source (https://pubmed.ncbi.nlm.nih.gov/39301475/)

# chronicfatiguesyndrome # fibromyalgia

Neurological Lyme disease, or neuroborreliosis, is when an infection with the bacteria that causes Lyme disease affects ...
09/25/2024

Neurological Lyme disease, or neuroborreliosis, is when an infection with the bacteria that causes Lyme disease affects the nervous system. Neuroborreliosis occurs when the bacteria that causes Lyme disease penetrates the central nervous system and causes symptoms including facial palsy, meningitis, nausea, vomiting, vertigo, and neck stiffness. When Lyme disease progresses (becomes chronic), the peripheral nerves can be affected, causing numbness, tingling in hands and feet, and radicular pain.

The researcher’s aim in this new article was to summarize similarities and differences between dementia-like syndromes in neurological Lyme disease and primary neurodegenerative conditions. Dementia is an umbrella syndrome associated with memory impairment and loss, cognitive disturbances, and personality changes to such an extent that they interfere with daily life. One study found that Lyme dementia without other comorbidities has a better outcome following antibiotic treatment. Another study reviewed in this article reported that dementia-like syndrome has a faster onset than primary dementia, such as Alzheimer’s. This is a clue that there may be an underlying infectious cause like Lyme disease.

Have you experienced dementia-like syndrome from Lyme disease? If so, did treatment improve the dementia? Comment below.

Click the link in the bio for the source and to read about neurological Lyme disease (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403646/) (https://drtoddmaderis.com/neurological-lyme-disease)

A team of gastroenterologists at Houston Methodist Hospital recognized a common theme in a group of young women who were...
09/15/2024

A team of gastroenterologists at Houston Methodist Hospital recognized a common theme in a group of young women who were experiencing GI symptoms with intractable nausea and vomiting, and also GERD and constipation. These women also exhibited or reported a history of hypermobility (hEDS), postural orthostatic tachycardia syndrome (POTS), and mast cell activation syndrome (MCAS). The women’s GI symptoms were challenging to manage, leading the authors to believe their digestive symptoms may be related to their systemic syndromes.

Digestive symptoms are now recognized to be associated with other systems in the body, such as the nervous, endocrine, and musculoskeletal. In the past, they were referred to as functional gastrointestinal disorders but are now called disorders of the gut-brain interaction (DGBI), acknowledging the belief that symptoms originate from a bidirectional interaction between the brain and the gut. Now, if we could get gastroenterologists to accept diet affects digestive health!

If you experience digestive symptoms and have MCAS, EDS, or POTS (or a combination), or if you are a physician who treats these disorders, I strongly encourage you to read this article.

Click the link in the bio for the source (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348541/) (https://drtoddmaderis.com/mast-cell-activation-syndrome)

Intestinal inflammation leading to hyperpermeability has been linked to various autoimmune conditions. The small intesti...
09/13/2024

Intestinal inflammation leading to hyperpermeability has been linked to various autoimmune conditions. The small intestinal barrier is designed to allow small molecules of nutrients to pass into the blood stream. However, when inflamed, the spaces between cells allow larger molecules, proteins, bacteria, and more to cross the barrier. Once across this barrier, larger molecules enter the bloodstream and trigger an immune reaction. Antibodies that form against these “foreign” substances can cross-react with our tissue, leading to autoimmunity.

This new study measured leaky gut markers, bacterial dysbiosis, and inflammatory cytokines in people with rheumatoid arthritis (RA) and compared them to age and sex-matched controls. About 1.5 million people suffer from RA, and women are three times more likely to develop RA than men. Few studies have looked at the relationship between leaky gut markers and RA, and none that also measured intestinal dysbiosis and inflammatory markers. Not surprisingly, the people with RA had elevated markers of leaky gut, dysbiosis, and inflammation when compared to controls.

How does conventional medicine treat RA (and most autoimmune conditions)? Most commonly with expensive immune-suppressing drugs. Suppressing the immune system can lead to other issues. In addition, if the underlying cause(s) are not treated, there is an increased risk of developing additional autoimmune conditions. Naturopathic and functional medicine seeks to find the root cause and effectively treat it. If you suffer from an autoimmune condition (or any inflammatory condition), I encourage you to get properly tested for leaky gut syndrome. I use the Cyrex [IG & X ] Array 2 in my practice.

Click the link in the bio for the source and to read more about leaky gut syndrome
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354395/) (https://drtoddmaderis.com/leaky-gut-syndrome)

Anyone with chronic tickborne infections knows the uphill battle of finding effective therapies. Chronic viral infection...
09/11/2024

Anyone with chronic tickborne infections knows the uphill battle of finding effective therapies. Chronic viral infections present a similar challenge. Often, people resort to combinations of antibiotics, anti-virals, or herbal medicine in an attempt to eradicate the infection. However, this can be a lengthy process with uncertain outcomes. Enter SOT, a therapy that has shown a promising success rate in blocking a gene sequence necessary for the infection's survival.

As people seek new and effective therapies, SOT has emerged as a promising solution for chronic tickborne and viral infections. SOT, or supportive oligonucleotide therapy, disrupts a gene sequence crucial for the infection’s survival. By silencing this gene, the virus or bacteria is rendered incapable of producing proteins for metabolism and survival.

I recently began using SOT with my patients who suffer from Lyme disease and co-infections, Epstein-Barr virus (EBV), and other chronic infections. Swipe to see the infections that SOT is available for. Click the link in the bio to read more about SOT for chronic infections (https://drtoddmaderis.com/sot-for-lyme-disease)

Mitochondria are often thought of as the powerhouse inside of cells because they produce the energy currency, ATP, requi...
09/08/2024

Mitochondria are often thought of as the powerhouse inside of cells because they produce the energy currency, ATP, required for most functions in the body. We also know immune cells have high energy demands, so there is a greater concentration of mitochondria in immune cells. This new review article introduces the innovative concept of intracellular immunity conducted by mitochondria as critical immune signaling hubs.

The authors of this publication also propose that mitochondria serve broader immune functions, including presenting antigens to other immune cells and regulating the immune system. Regulated mitochondrial function provides therapeutic potential in managing inflammation and autoimmunity in chronic disease. Understanding the role of mitochondria in immune system function provides another critical reason to ensure mitochondrial function is optimal in recovery from complex chronic illness.

Click the link in the bio for the source and to read about repairing mitochondria
(https://drtoddmaderis.com/the-importance-of-phosphatidyl-choline-in-chronic-diseases)
(https://www.sciencedirect.com/science/article/pii/S2213231724003094)

Chronic fatigue syndrome (ME/CFS) is a multisystem condition characterized by persistent fatigue, post-exertion symptom ...
09/06/2024

Chronic fatigue syndrome (ME/CFS) is a multisystem condition characterized by persistent fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, orthostatic intolerance, and more. Many mechanisms have been hypothesized and studied over the years in an attempt to explain the pathophysiology of ME/CFS, but no clear cause has been identified. Another challenge is the need for diagnostic biomarkers for ME/CFS.

Previous studies have demonstrated cardiovascular and hematological pathology in ME/CFS. In this new study of 15 patients with ME/CFS and 10 controls not previously infected with SARS CoV-2, researchers (including Amy Proal [X - ]) measured differences in protein expression in plasma samples. They discovered 24 proteins significantly increased in the ME/CFS group and 21 significantly downregulated proteins. The ME/CFS group had increased protein related to clotting, suggesting a dysregulated coagulation system and blood vessel dysfunction. The complement system was also downregulated, indicating immune system dysfunction. Although this was a small study, the results provide insight into future research for developing diagnostic and treatment tools.

Click the link in the bio for the source (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253362/)

Biofilms are a complex community of microbes surrounded by a protective matrix. Think of biofilms as a little city with ...
09/04/2024

Biofilms are a complex community of microbes surrounded by a protective matrix. Think of biofilms as a little city with their communication system, food supply, and protective police. Up to 80% of bacteria live in biofilms, allowing them to survive in hostile environments and evade the immune system. Bacterial resistance is up to 1000 times greater in a biofilm than in free-living bacteria.

Hope on the Horizon: biofilms in Lyme carditis, previously unexplored due to lack of a suitable model, have now been revealed in a groundbreaking study. The detection of Lyme bacteria Borrelia forming biofilms in mouse heart tissue, along with the elevation of C-reactive protein (CRP) near the biofilms, suggests that biofilms may trigger inflammation in heart tissue. These promising findings could pave the way for new directions in treating Lyme carditis.

Click the link in the bio for the source and to read about Lyme carditis (https://www.mdpi.com/2076-2607/12/9/1766) (https://drtoddmaderis.com/what-is-lyme-carditis)

Over 65 million people are affected by Long COVID, and a third of those experience neurological symptoms, including chro...
09/01/2024

Over 65 million people are affected by Long COVID, and a third of those experience neurological symptoms, including chronic fatigue syndrome (ME/CFS), anxiety, and depression. Over the past four years, there have been multiple theories and evidence that might explain the pathophysiology of Long COVID. Persistent SARS CoV-2 virus, reactivated infections, inflammation, and autoimmunity are some causes identified in research settings. In addition, there is evidence that major depressive disorder and ME/CFS are associated with bacterial translocation seen in leaky gut syndrome.

The authors of the current study set out to determine what role these variables play in Long COVID. Markers for various pathophysiological causes were measured in ninety patients with Long COVID and ninety healthy controls.

The results of this unique study were surprising. Swipe to see them.

Click the link in the bio for source (https://onlinelibrary.wiley.com/doi/10.1002/jmv.29864) (https://drtoddmaderis.com/leaky-gut-syndrome)

The zoonotic bacteria Bartonella has an affinity for the lining of blood vessels. When the bacteria localizes in blood v...
08/30/2024

The zoonotic bacteria Bartonella has an affinity for the lining of blood vessels. When the bacteria localizes in blood vessel walls, it reduces blood flow to tissues. Previous research has shown that an infection with Bartonella is associated with neurological and psychiatric symptoms. The investigators in this new study hypothesized an association between pathologically accelerated decline in cognitive function in aging and infection with Bartonella.

Blood samples were collected from older people with past and present Bartonella infection with and without cognitive decline. Contrary to their theory, people with mild cognitive impairment (MCI) were not more likely than people without to have an infection with Bartonella. The authors stated, “Conclusions require caution, as our study was limited by the small number of cases with MCI. Overall, our results identified a higher than previously recognized rate of exposure and infection with Bartonella spp. in this older study population but does not support a specific role for such infection in MCI.”

Click the link in the bio for the source (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307060)

A question commonly raised in the mold-related illness community is whether to treat if one is still exposed to mold in ...
08/28/2024

A question commonly raised in the mold-related illness community is whether to treat if one is still exposed to mold in one's environment. Reducing one's mycotoxin burden, even while exposed to mold, reduces the effect mold has on the immune system, inflammation, and oxidative damage.

It is preferred to be in a mold-free environment; however, this is not always possible immediately. In the meantime, reducing mycotoxin levels with binders, glutathione, and other therapies supports your health. I think of this like being in a canoe with a hole in it. Paling out the water slows the rate at which the canoe sinks!

To set the record straight, do whatever you can to reduce your mycotoxin burden, even if your environment is not free of mold and mycotoxins!

Click the link in the bio to read how mold causes more than CIRS (https://drtoddmaderis.com/chronic-inflammatory-response-syndrome)



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