
08/07/2025
Amen!
I was just counselling a new patient earlier today about the risks of the anticholinergic effects of Benedryl. The main ingredient in most OTC sleeping medications, diphenhydramine has significant anticholinergic effects along with it's sedative and antihistamine effects. Benedryl knocks about 15 IQ points off of you 12-14 hours after taking it.
If you take Sominex or some other OTC sleeping medication and notice mental dulling the following afternoon, it might very well be the diphenhydramine. This is especially dangerous in the elderly.
I have felt for quite some time that the FDA should remove it from our shelves.
In a new review, experts call for the removal of diphenhydramine from over-the-counter and prescription markets in the United States, saying it’s outdated, dangerous and eclipsed by safer alternatives.