Dr. Dee Bonney

05/30/2026

I was a six-figure ER doctor getting suicidal on shift.

Not because of the patients. The patients I could handle.

Because I was trapped in a career that was destroying me, and I couldn't say it out loud.

I had built a life that looked correct from the outside. ER physician. Twenty-five years in. The word "fine" became the most dishonest sentence I said every week.

I tried three SSRIs. Each one for long enough. The receptors stopped responding. I thought I was getting worse. I now know there is a word for it. Tachyphylaxis.

I thought I needed to try harder. Push through. White-knuckle it.

Willpower does not grow dendrites.

The first IV ketamine infusion I had personally shifted something I had been trying to shift for a decade.

I built AlphaOmega Wellness for the person I used to be. The hiding-it, "I'm fine," still-showing-up-but-not-actually-present version of me.

If you have been the same person, I want you to know two things. You are not weak. You are dysregulated. And dysregulation is fixable.

05/29/2026

"Treatment resistant" isn't a diagnosis. It's what happens when the system runs out of ideas. And then calls it your fault.

The clinical definition is two failed antidepressants. The phrase becomes much heavier than the definition.

It starts to mean broken. Can't be fixed. Permanent.

Here's the truth from 800 patients in my chair. The receptor stopped responding to one drug. The brain did not stop responding to treatment.

Different problem. Different door.

You don't need a label. You need a brain that works.

How long have you been carrying the label?

05/29/2026

Andrew Huberman got the neuroscience right.

But after 800+ patients and 5,000 ketamine infusions, we’ve learned there’s another side to the story that podcasts and research papers can’t fully capture.

The high-functioning executives, entrepreneurs, and professionals who look “fine” on the outside are often the ones struggling the most internally.

Functional. Productive. Successful.
But emotionally numb, exhausted, and disconnected.

In this new video, we break down:
• What the research says about ketamine
• What clinical experience reveals that studies can’t measure
• Why some patients transform — and others don’t
• The missing piece in modern mental health treatment

Watch here:

Andrew Huberman's ketamine episode reached millions. He got the neuroscience right. But there's a layer of clinical reality — the part that only shows up aft...

05/29/2026

High-functioning executives and professionals are the most underserved population in mental health. They're functional but numb. They don't need mental health treatment. They need brain health treatment.

05/29/2026

Andrew Huberman did a great podcast on ketamine. Solid neuroscience. Worth your time.

The part he didn't have room for is what happens in the 72 hours after the infusion.

That window is everything. Ketamine blocks NMDA receptors. Triggers a glutamate burst. BDNF peaks 24 to 72 hours later. The brain becomes more responsive to inputs than at almost any other time.

Whatever you put into the brain in those 72 hours, you encode.

A patient who drives home and ruminates for two days encodes the rumination. The medicine did its job. The brain just had no new inputs.

A patient who treats those 72 hours like the most important 72 hours of the month encodes something different. New conversations. New patterns. The thing they have been avoiding for years.

That is brain repair. Not the chemistry. The integration.

Full video on YouTube. Link in the comments.

05/28/2026

If your antidepressant stopped working, you didn't stop responding. The receptor stopped responding.

There is a difference. The difference matters.

SSRIs increase serotonin availability. Over time, the receptors that respond down-regulate. The brain adapts. The phenomenon has a name. Tachyphylaxis.

This is not a personal failure. This is the brain doing what brains do.

The receptor layer stopped responding to that particular drug. The brain has not lost the ability for treatment.

It just lost the ability to respond to that treatment.

Different problem. Different door. You're not broken. You're dysregulated. And dysregulation is fixable.

Drop a comment if this is the first time someone has explained it that way to you. I want to know how long you have been carrying the wrong word.

05/27/2026

The infusion doesn't rewire you. What you do in the 72 hours after the infusion rewires you.

05/26/2026

What four infusions can do to a person who's been carrying ten years of failed treatments.

She walked in dreading every morning. Two months later — four infusions into a six-infusion series — she said this:

"I'm ten times lighter when I get to work. I don't dread getting up anymore."

Real patient. 47 years old. Name changed for privacy.

She'd been on six different antidepressants over a decade. Each one helped for a while. Each one stopped working. She'd been labeled "treatment resistant" for years. She walked into our office certain she was broken.

Here's what was actually happening biologically.

SSRIs increase serotonin availability. Over time, those receptors down-regulate — the brain adapts to the extra serotonin and the medicine stops landing. That process has a name. It's called tachyphylaxis. And it's not a personal failure. It's brain adaptation.

The brain hadn't lost the ability for treatment. It just stopped responding to that particular treatment at that receptor level.

IV ketamine works in a different lane entirely. Synaptic neuroplasticity. Brain structure. Not the receptor layer.

Different question. Different door.

After 800 patients, I'm sure of this:

Most of the people walking around with the "treatment resistant" label are not resistant. They're receptor down-regulated. And that's a completely different problem with a completely different solution.

If you've been carrying that label for years — wondering if you're the small percentage of cases that can't be helped — I'd encourage you to ask a different question.

Not "what's wrong with me." But "what mechanism am I trying to fix, and am I trying to fix it through the right door?"

Who in your life has been carrying that label longer than they should have?

05/24/2026

The brain fog lifted.

That's how she described it.

"I could think again."

59-year-old woman. Fibromyalgia, treatment-resistant depression, and what she called "twenty years of gray."

After IV ketamine: clarity. Not happiness. Clarity.

The ability to think, plan, and feel like herself again.

Brain health, not mental health.