12/06/2025
Lifestyle plays a major role, sometimes even more than genetics. Obesity is the strongest lifestyle-related cause of endometrial cancer—about 40% of cases are linked to excess body fat. This is because fat tissue converts hormones into estrogen, creating a constant high-estrogen environment. Insulin resistance, prediabetes, and metabolic syndrome also increase risk by raising insulin and growth-factor levels that stimulate cell growth in the uterus. A diet high in sugar, refined carbs, and processed foods can worsen these changes. Smoking, long-term physical inactivity, and chronic inflammation add to the risk as well. Improving diet quality, losing even a small amount of weight, and staying active can significantly reduce the chances of developing endometrial cancer.