10/23/2025
Neuroscience just posted this a couple of hours ago, and it caught my eye immediately. As a Doctor of Clinical Nutrition, studies like this always pique my interest.
Here’s the thing — any diet that requires you to cut out entire food groups or go against your body’s natural chemistry is bound to have consequences eventually.
So, what did the study find?
In a mouse-model study, animals fed a ketogenic diet for an extended period (about 8 months, which would equal decades in human years) developed significant metabolic dysfunction.
Specifically:
They showed fatty liver buildup and signs of liver dysfunction, especially in males.
They also had trouble regulating blood sugar because the pancreatic β-cells (which release insulin) became stressed and impaired.
Some effects reversed when the diet stopped (a slight relief!), but the long-term implications were still concerning.
I agree with the caution that while mice aren’t humans, the findings suggest that long-term, ultra-high-fat / very-low-carb diets might carry hidden risks — mainly when used for weight loss rather than medical therapy (there is a difference).
Here’s the key — short-term results don’t always equal long-term health.
Our bodies aren’t meant to live in constant restriction or survival mode.
If you’ve tried keto or are thinking about it, it’s worth asking:
Is this truly sustainable for my body, my life, and my long-term health?
My takeaway: Listen to your body (and the science), not just the trends.
Sustainable health rarely comes from extremes.
Long-Term Keto Diet May Damage Your Body
A new study finds that the ketogenic diet’s short-term benefits may come at a long-term cost.
Researchers discovered that extended keto feeding caused fatty liver buildup and disrupted blood sugar control due to pancreatic stress.
Though some effects reversed when the diet stopped, males were particularly vulnerable to liver dysfunction.
The results call for caution when using keto as a long-term strategy for weight or metabolic management.