07/27/2025
I hear this ALL the time:
“I was told I will never need progesterone because I don’t have a uterus.”
Chief complaint: poor sleep, mood swings, weight gain (‼️)
Progesterone has so many other benefits besides uterine protection. Even without a uterus, many women still benefit from replenishing progesterone using bio-identical progesterone.
✅ 1. Neuroprotective Effects (Brain Health)
• Progesterone supports cognitive function, helps regulate mood, and may protect against neurodegenerative diseases like Alzheimer’s.
• It has calming, anti-anxiety effects and modulates GABA receptors in the brain, which may improve sleep and mood.
✅ 2. Bone Health
• Progesterone supports osteoblast (bone-building cell) activity.
• When used in balance with estrogen, it may help maintain or improve bone density, reducing the risk of osteoporosis.
✅ 3. Cardiovascular Health
• Some evidence suggests progesterone may support vascular relaxation, reduce inflammation, and help maintain healthy lipid profiles.
• Natural (bioidentical) progesterone appears neutral or beneficial for heart health, unlike some synthetic progestins (like medroxyprogesterone, norethindrone, desogestrel and drospirenone).
✅ 4. Sleep Quality
• Progesterone has sedative properties and can improve deep sleep, especially in pre and postmenopausal women or those with hormone imbalance after hysterectomy.
✅ 5. Breast Protection (Controversial but Noteworthy)
• Bioidentical progesterone may counterbalance the proliferative effects of estrogen on breast tissue, potentially reducing breast cancer risk.
✅ 6. Mood Stabilization & Anxiety Reduction
• Progesterone helps reduce irritability, anxiety, and depressive symptoms, particularly in women sensitive to hormonal shifts.
✅ 7. Skin, Hair, and Metabolism Support
• It may contribute to healthier skin and hair, and modulate insulin sensitivity and fat storage.
