05/24/2026
PERIMENOPAUSE:
This is a highly turbulent time in a woman's life. Hormones begin to decline and fluctuate. This can lead to various uncomfortable symptoms, and also increases the risk for several diseases.
Progesterone is the first hormone that really begins to decline and can lead to some pronounced symptoms. These often include increasing breast tenderness, mood swings, insomnia, fatigue, anxiety, irritability, depression, abdominal bloating, migraines, and irregular menstrual cycles.
Several of the symptoms frequently result in prescriptions for medications that are not addressing the problem, such as antidepressants or anxiety medication, migraine medications, NSAIDs, or sleep aids.
It is a commonly held belief that progesterone serves a single role in the body, which is protection of the uterus, and preparation of the uterus for implantation of an egg for pregnancy. Progesterone, however, has many more functions throughout the body.
Progesterone Functions:
Reproduction (implantation and maintaining the uterine lining).
Regulates the menstrual cycles.
Mood regulation.
Neuroprotective. Supports healthy cognitive function.
Brain production and regeneration, including production of myelin
Sedative effects (calms the brain).
Immune regulation (autoimmunity).
Maintenance of healthy bone (osteoblast proliferation).
If you have been unfortunate enough to have a hysterectomy, gynecology may tell you that progesterone is unnecessary because you no longer have a uterus. They may put you on estrogen replacement, but this will contribute to a state of estrogen dominance. That can result in many of the symptoms associated with perimenopause as progesterone would naturally decline but estrogen levels continue to fluctuate. When you review the functions of progesterone, you can see why this may not be a good idea.
We evaluate women in perimenopause or postmenopause and provide hormone support therapy for those that are interested. You do not need to struggle through this.