11/04/2025
GABA for memory, mood, and spatial awareness
In a world with an aging population, doctors wanted to find ways to prevent cognitive decline. In two separate, coordinated studies, each with 60 healthy adults over age 40, participants took a placebo or, in one study, 100 mg of gamma-aminobutyric acid (GABA), and in the second, 200 mg of GABA, per day.
After 12 weeks, compared to placebo and to the start of the study, those taking 100 mg of GABA could better identify and analyze space, visual forms within it, and the relationship between the two. Delayed memory—the ability to recall after a period of time—also improved. In addition to these benefits, the 200 mg group saw improvements in non-verbal reasoning, which is the capacity to understand music and math, and to identify objects through touch.
Quality of life also improved in both GABA groups, including better physical function, self-reported vitality, and feelings of mental well-being. In addition, those taking 200 mg of GABA had increased levels of insulin-like growth factor (IGF-1), which enters the brain, activating brain function, and which doctors believe may be GABA’s mechanism of action.
Reference: Japanese Pharmacology and Therapeutics; 2020, Vol. 48, No. 3, 461-74
Message from Dave the Nutritionist.
Please check with you doctor before taking any GABA supplements, as they can interact with medications.