01/21/2026
While this is only a review, it is what I see in practice and why I love comprehensive stool testing:
âNow, a comprehensive new review published in Brain, Behavior, and Immunity confirms what I've observed clinically: butyrate, a short-chain fatty acid produced by your gut bacteria, shows remarkable promise as an intervention for depression.
Butyrate sits at the intersection of gut health, inflammation, and brain function. When your gut produces less of itâoften due to dysbiosis, chronic stress, or a low-fiber dietâyou lose its protective effects, leading to increased intestinal permeability, systemic inflammation, and downstream effects on mood.â -Chris Kressor
https://pubmed.ncbi.nlm.nih.gov/41429215/?utm_source=klaviyo&utm_medium=email&utm_campaign=%28Wednesday%20Email%29%20From%20gut%20to%20glee%3A%20The%20butyrate-depression%20connection&utm_term=new%20review&utm_content=new%20review&_kx=Ab0X7EO5NOlr3kYuJazQ38I8FPYXx0H6a6bH-_fetL0.my75y6
Korenblik V, Schilder NKM, de Lange IGS, et al. From gut to glee: Is butyrate a promising antidepressant? A systematic review and mechanistic insights. Brain Behav Immun. 2026;132:106237. doi:10.1016/j.bbi.2025.106237
BDNF, Brain-derived neurotrophic factor; CRS, Chronic restraint stress; CSD, Chronic social defeat; C**S, Chronic unpredictable mild stress; DASS, Depression, anxiety, Stress Scales; EPM, Elevated plus maze; FMT, F***l microbiota transplant; FST, Forced swim test; HDAC, Histone deacetylase; HFD, Hig...