01/09/2021
If you catch COVID-19: How to Enhance your Immune System
1. Buy a pulse oximeter (it measures peripheral oxygen saturation):
SpO2 > 95 - safe zone
SpO2 90 to 94 - caution zone
SpO2 < 90 - low oxygenation zone (hospitalization recommended for evaluation of COVID pneumonia especially if it's in the low 80s).
2. Vitamin D: for dose check with healthcare provider - data from randomized control trials.
Vitamin K2 (mk7): for dose check with healthcare provider.
Magnesium: for dose check with healthcare provider.
K2 and Magnesium are often combined with vitamin D.
3. Quercetin: for dose check with healthcare provider.
4. NAC (N-acetyl cysteine): for dose check with healthcare provider.
5. EGCG: or dose check with healthcare provider.
6. Sleep: at least 7 hours of a good night of sleep (slow wave sleep - before midnight). Melatonin as an antioxidant and sleep aid (30min before bedtime).
7. Zinc: for dose check with healthcare provider.
8. Temperature elevation (Nobel Prize therapy): sauna or heating blankets. When showering alternate hot with cold water.
9. Isolation strategies (droplets and airborne): ventilation, hepa air filters, mask use.
10. Monoclonal antibodies: there are FDA emergency use authorization for these drugs. However, they are more effective when used in the beginning of the infection. One of them, made by Lilly, bamlanivimab (IV only), there was a randomized control trial. Talk to your healthcare provider about it.
References:
1. Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver, Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1911–1930, https://doi.org/10.1210/jc.2011-0385
2. Rastogi A, Bhansali A, Khare N, et alShort term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)Postgraduate Medical Journal Published Online First: 12 November 2020. doi: 10.1136/postgradmedj-2020-139065
3. Agrawal PK, Agrawal C, Blunden G. Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations. Natural Product Communications. December 2020. doi:10.1177/1934578X20976293
4. Peter Chen, M.D., Ajay Nirula, M.D., Ph.D., Barry Heller, M.D., Robert L. Gottlieb, M.D., Ph.D., Joseph Boscia, M.D., Jason Morris, M.D., Gregory Huhn, M.D., M.P.H.T.M., Jose Cardona, M.D., Bharat Mocherla, M.D., Valentina Stosor, M.D., Imad Shawa, M.D., Andrew C. Adams, Ph.D., et al., for the BLAZE-1 Investigators. SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19. https://www.nejm.org/doi/10.1056/NEJMoa2029849
5. Silva ESME, Ono BHVS, Souza JC. Sleep and immunity in times of COVID-19. Rev Assoc Med Bras (1992). 2020 Sep 21;66Suppl 2(Suppl 2):143-147. doi: 10.1590/1806-9282.66.S2.143. PMID: 32965373.
6. Irwin MR, Opp MR. Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology. 2017 Jan;42(1):129-155. doi: 10.1038/npp.2016.148. Epub 2016 Aug 11. PMID: 27510422; PMCID: PMC5143488.
7. Baronzio G, Gramaglia A, Fiorentini G. Hyperthermia and immunity. A brief overview. In Vivo. 2006 Nov-Dec;20(6A):689-95. PMID: 17203747.