07/24/2025
Our Summary of Esophageal Cancer
If you have had reflux for >5 years, get an upper endoscopy to screen for esophageal cancer.
Esophageal cancer is a malignancy that arises from the esophagus, the muscular tube that connects the throat to the stomach. There are two primary types:
1. Squamous Cell Carcinoma – Originates from the squamous cells lining the upper and middle parts of the esophagus; more common in areas with to***co & alcohol use.
2. Adenocarcinoma – Develops from glandular cells, typically in the lower esophagus, often associated with Barrett’s esophagus & chronic gastroesophageal reflux disease (GERD).
Risk Factors:
• Smoking and heavy alcohol use (squamous)
• Chronic GERD & Barrett’s esophagus (adenocarcinoma)
• Obesity
• Male s*x and older age
• Diet low in fruits/vegetables
• Human papillomavirus (HPV) infection (less common)
Symptoms:
• Dysphagia (difficulty swallowing)
• Weight loss
• Chest pain or discomfort
• Hoarseness or chronic cough
• Vomiting or regurgitation of food
Diagnosis:
• Endoscopy with biopsy (definitive)
• Barium swallow for structural assessment
• CT, PET-CT, or endoscopic ultrasound (EUS) for staging and metastasis detection
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Staging Esophageal Cancer (TNM System – AJCC 8th Edition)
Staging is crucial for determining prognosis and treatment. It uses the TNM classification:
T – Tumor (Depth of Invasion)
• Tis: Carcinoma in situ (high-grade dysplasia)
• T1: Invades lamina propria, muscularis mucosae, or submucosa
• T1a: Limited to mucosa
• T1b: Invades submucosa
• T2: Invades muscularis propria
• T3: Invades adventitia
• T4: Invades adjacent structures
• T4a: Resectable (pleura, pericardium, diaphragm)
• T4b: Unresectable (aorta, vertebral body, trachea)
N – Nodes (Lymph Node Involvement)
• N0: No regional lymph node metastasis
• N1: 1–2 regional lymph nodes
• N2: 3–6 regional lymph nodes
• N3: ≥7 regional lymph nodes
M – Metastasis
• M0: No distant metastasis
• M1: Distant metastasis present
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Stage Groupings (Simplified):
Stage T N M
0 (in situ) Tis N0 M0
I T1 N0 M0
II T2–T3 N0 or N1 M0
III T3–T4a N1–N3 M0
IV Any T Any N M1
Note: Location (upper, middle, lower esophagus), histology (squamous vs. adeno), and grade also affect stage classification.
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Staging Modalities:
• Endoscopic Ultrasound (EUS): Best for T & N staging
• CT/PET-CT: Detects distant metastasis
• Laparoscopy/Thoracoscopy: May be used in select patients to evaluate resectability. When the tumor is low, a staging laparoscopy with washing can rule-out malignant peritoneal disease.