Michael D. Lesem, MD, PA

02/01/2026

💭 Spravato vs Ketamine — What’s the difference? (Houston edition)

We get this question all the time, so here’s a quick breakdown:

Spravato®
• FDA-approved
• Nasal spray
• Given in-office with monitoring
• Often covered by insurance
• Used for treatment-resistant depression

Ketamine (IV/IM/lozenge)
• Off-label for depression
• Different forms (IV, injection, oral)
• Typically cash-pay
• May work faster for some people

✨ Both can be effective — the right option depends on your symptoms, history, and what fits your life best.

We’re happy to talk through options and see what makes sense for you or someone you care about here in Houston.
📩 Message us or 📞 call the office to learn more.

02/01/2026

💙 Houston friends — we’re accepting new patients!

We’re currently welcoming new patients and truly appreciate referrals from our community. If you know someone in the Houston area who could benefit from thoughtful, compassionate psychiatric care, sending them our way is one of the best ways to help.

📞 Call us(832-538-1479) or 📩 email (into@LesemMD.com) us to get started.
Thank you for continuing to trust and support our practice — Houston really does show up for each other.

Campanile South Building (next to The Pit Room)

4306 Yoakum Blvd, Ste 230
Houston, TX 77006

Two Block west of Montrose Blvd

11/20/2025

07/23/2025

🌟 Struggling with ADHD, Anxiety, Depression, or Bipolar Disorder?

We’re here to help. At Michael Lesem MD, PA, we specialize in compassionate, evidence-based psychiatric care — including Esketamine treatment, medication management, and ADHD evaluations.

🧠 Take the first step toward feeling better.
📍Located in Houston, TX (77006)
🌐 Visit us at www.LesemMD.com

05/15/2025

Learn more about Spravato Esketamine used to treat TRD⭐️💚

This page is intended for US residents only.

Important Safety Information: https://www.spravato.com/ -safety-information
Full Prescribing Information, including Boxed WARNINGS: https://jmc.link/3RMl24d

09/16/2024

🌟 Find Relief from Depression with FDA-Approved Spravato in Houston 🌟

Are you struggling with treatment-resistant depression? At Michael Lesem MD PA - Neuropsychiatry Specialists, we're here to help! We offer Spravato® (esketamine), an innovative and FDA-approved nasal spray treatment that provides fast-acting relief.

🧠 Why Choose Spravato?
✅ Clinically proven for treatment-resistant depression
✅ Fast-acting, with noticeable improvement within hours
✅ Administered in a safe and comfortable environment
✅ Expert medical support throughout your journey

Located in the heart of Houston, we're here to guide you to a brighter future. Don't let depression hold you back—take the first step towards feeling like yourself again.

📞 Call us at 832-538-1479 to schedule a consultation or visit https://www.lesemmd.com/ to learn more!

06/27/2024

Spravato Esketamine ✨

Transform your mental health with expert care at our Houston Esketamine Spravato Treatment Center. Start your journey today.🩺

06/26/2024

Experience breakthrough treatment at Houston's premier Esketamine Spravato Center. Specialized care for lasting relief.

06/12/2024

In honor of Independence Day our office will be closed the week of July 1st - July 5th. We hope everyone has a wonderful day.

02/22/2024

Spravato Treatment VS IV Ketamine Infusion

01/10/2024

Dr. Michael Lesem, MD is a neuropsychiatry specialist in Houston, TX and has over 42 years of experience in the medical field. He graduated from University of Texas Health Sciences Center at Houston McGovern Medical School in 1981.

11/02/2023

Spravato is one of the biggest breakthroughs in treating Treatment Resistant Depression in the past 50 years ! 💫

Feel free to contact our office for more information !⭐️

Give us a call at (832) 538-1479 or email us at info@LesemMD.com 📲