10/03/2025
Trintellix (generic name: vortioxetine) is a prescription medication used to treat major depressive disorder (MDD) in adults. It is known for having a unique mechanism of action compared to other antidepressants.
⸻
🔹 Key Information About Trintellix
✅ Uses:
• Treatment of Major Depressive Disorder (MDD) in adults.
🧠 How It Works:
• Trintellix is a serotonin modulator and stimulator.
• It affects serotonin receptors and inhibits the reuptake of serotonin (5-HT) in the brain.
• Its multimodal action helps regulate mood and emotional state.
⸻
💊 Dosage:
• Typically starts at 10 mg once daily.
• May be adjusted to 5 mg to 20 mg daily, depending on individual response and tolerability.
• Can be taken with or without food.
⸻
⚠️ Common Side Effects:
• Nausea
• Constipation
• Vomiting
• Dizziness
• Sexual dysfunction (less common than with SSRIs)
• Dry mouth
🔴 Serious Side Effects:
• Serotonin syndrome (especially if combined with other serotonergic drugs)
• Suicidal thoughts (particularly in young adults and adolescents)
• Abnormal bleeding
• Hyponatremia (low sodium)
• Mania/hypomania (in bipolar disorder patients)
⸻
🚫 Drug Interactions:
• MAOIs – Do not use with or within 14 days of taking an MAOI.
• Other serotonergic drugs – Risk of serotonin syndrome.
• Blood thinners or NSAIDs – May increase risk of bleeding.
• CYP2D6 inhibitors – May increase levels of Trintellix.
⸻
❗ Warnings & Precautions:
• Monitor for worsening depression or suicidal thoughts, especially during the first few weeks.
• Use caution in patients with a history of bipolar disorder, seizures, or bleeding disorders.
• Not approved for use in children.
⸻
🤰 Pregnancy & Breastfeeding:
• Use only if the benefit outweighs the risk during pregnancy.
• It’s unknown if Trintellix is safe during breastfeeding – consult a healthcare provider.
⸻
🔄 Discontinuation:
• Tapering off is not usually required, but consult your doctor before stopping.
• Some patients may still experience withdrawal symptoms if stopped abruptly.