11/15/2025
Date: November 10, 2025
Source: Columbia University Irving Medical Center
Summary:
“Researchers identified SGK1 as a key chemical connecting childhood trauma to depression and suicidal behavior. High SGK1 levels were found in the brains of su***de victims and in people with genetic variants linked to early adversity. Drugs that block SGK1 could offer a new kind of antidepressant, especially for patients resistant to SSRIs.”
https://www.sciencedaily.com/releases/2025/11/251110021114.htm
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https://www.sciencedaily.com/releases/2025/11/251110021114.htm
Researchers identified SGK1 as a key chemical connecting childhood trauma to depression and suicidal behavior. High SGK1 levels were found in the brains of su***de victims and in people with genetic variants linked to early adversity. Drugs that block SGK1 could offer a new kind of antidepressant, e...