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The adrenal cortex, specifically the zona fasciculata and zona reticularis, synthesizes 11-deoxycortisol from 17-hydroxy...
10/30/2025

The adrenal cortex, specifically the zona fasciculata and zona reticularis, synthesizes 11-deoxycortisol from 17-hydroxyprogesterone. This intermediate is then converted into cortisol through the catalytic action of the enzyme 11β-hydroxylase. Consequently, quantifying 11-deoxycortisol in serum or plasma serves as a useful diagnostic marker for identifying 11β-hydroxylase deficiency, the second most common form of congenital adrenal hyperplasia (CAH). This enzyme defect leads to reduced cortisol synthesis, which stimulates excess secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland. The impaired enzymatic conversion also causes accumulation of precursor steroids. Moreover, the drug metyrapone, which specifically inhibits 11β-hydroxylase, is employed in clinical settings to evaluate the integrity of the hypothalamic–pituitary–adrenal (HPA) axis by measuring post-administration levels of 11-deoxycortisol, ACTH, and cortisol. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55d8ff98-cfbd-46fe-a740-1a0383300407

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthr...
10/29/2025

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthrough that enhances the precision and power of our platform.

We’re proud to be among the first to achieve this milestone in linking resistance data to specific pathogens, driving smarter and faster clinical insights.

BRCA1/2 germline testing is essential in breast cancer risk assessment and management. Mutations in these tumor suppress...
10/28/2025

BRCA1/2 germline testing is essential in breast cancer risk assessment and management. Mutations in these tumor suppressor genes impair DNA repair through homologous recombination, predisposing carriers to early-onset and bilateral breast cancers. Testing is recommended for patients with a family history of breast or ovarian cancer, triple-negative breast cancer diagnosed before age 60, or male breast cancer. Identifying a BRCA1 or BRCA2 mutation influences clinical decisions such as intensified surveillance with MRI, prophylactic mastectomy, or salpingo-oophorectomy. In metastatic or high-risk cases, PARP inhibitors offer targeted therapy exploiting defective DNA repair mechanisms. Genetic counseling is crucial to interpret results and guide cascade testing among relatives, promoting early detection and personalized preventive strategies against hereditary breast cancer. Learn more about the testing with Medical Database.

PD-L1 is a key immune checkpoint biomarker. Its expression on tumor cells allows evasion of T-cell–mediated immunity, wh...
10/23/2025

PD-L1 is a key immune checkpoint biomarker. Its expression on tumor cells allows evasion of T-cell–mediated immunity, while blockade with PD-1/PD-L1 inhibitors enhances antitumor immune activity. Several PD-L1 inhibitors, including atezolizumab, durvalumab, nivolumab, and pembrolizumab, are approved for clinical use across multiple cancer types. The PD-L1 assay is a qualitative immunohistochemical test using Monoclonal Rabbit Anti-PD-L1. It is FDA-approved as a companion diagnostic for multiple tumor types, including Non-small cell lung cancer (NSCLC), Squamous cell carcinoma of the head and neck (SCCHN) and Urothelial carcinoma (UC) and provides essential information for patient selection in immunotherapy. Expression levels guide therapeutic decisions regarding the use of immune checkpoint inhibitors such as nivolumab and pembrolizumab. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/676b6095-69a3-4f46-907f-3f9639628048

Plasminogen activator inhibitor-1 (PAI-1) is a primary regulator and inhibitor of the fibrinolytic system that acts by b...
10/23/2025

Plasminogen activator inhibitor-1 (PAI-1) is a primary regulator and inhibitor of the fibrinolytic system that acts by binding and inhibiting plasminogen activators such as tPA and UPA. Elevated levels of PAI-1 may suppress fibrinolysis leading to increased risk of thrombosis. A common single nucleotide polymorphism (4G/5G) leads to differences in PAI-1 production. The 4G allele results in greater fibrinolytic inhibition than the 5G. The homozygosity or heterozygosity for the 4G PAI-1 allele is associated with increased thrombotic risk, myocardial infarction, pregnancy complications, and risk of meningococcal sepsis in children. No association of the 5G allele with these conditions has been shown. Prevalence of 4G/4G, 4G/5G, and 5G/5G genotypes are 31.8%, 46.6%, and 21.6% respectively. This assay may be used as an aid in the risk prediction and diagnosis of venous thromboembolism and related thrombotic disorders. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26da-eacb-4b10-94c3-7c033fa7521d

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and anti...
10/22/2025

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and antibiotic resistance, generating real-time, guideline-oriented pharmacotherapeutic recommendations according to detected microbial load and antimicrobial resistance genes. Learn more about our products:
www.medicaldatabase.com

Adenosine Deaminase (ADA) is an enzyme involved in purine metabolism and its main role is in the development and mainten...
10/22/2025

Adenosine Deaminase (ADA) is an enzyme involved in purine metabolism and its main role is in the development and maintenance of the immune system. ADA is produced by cells throughout the body and is also associated with the activation of lymphocytes. It can be used as adjunctive evidence in support of a diagnosis of infection by Mycobacterium tuberculosis. It is used mostly to test pleural fluid as an adjunct test to help rule in or rule out tuberculosis in pleural fluid. Mutation in the ADA gene results in an autosomal recessive disorder of purine metabolism known as Adenosine Deaminase Deficiency, also known as Severe Combined Immunodeficiency (SCID), primarily affecting lymphocyte development, viability and function. Increased levels of plasma ADA have been observed in some autoimmune diseases such as rheumatoid arthritis, psoriasis and sarcoidosis. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55bdbd8b-786d-41e2-bcdb-cea81e11b7b7

Renin is an enzyme that plays a role in maintaining salt and fluid levels in our body. Renin is produced by the juxtaglo...
10/17/2025

Renin is an enzyme that plays a role in maintaining salt and fluid levels in our body. Renin is produced by the juxtaglomerular apparatus cells in the kidney cortex in response to decreased blood pressure, salt concentration or fluid levels in our body. Renin performs its function by converting angiotensinogen to angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasopressor resulting in increased blood pressure. Angiotensin II also stimulates the adrenal cortex to produce the hormone aldosterone, which promotes the retention of sodium in the distal tubule, thereby increasing water retention. Plasma renin activity is usually used with the plasma aldosterone to screen for aldosteronism. The ratio of plasma aldosterone concentration to plasma renin activity is an effective screening test for primary aldosteronism with a sensitivity >95%. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26cd-8c63-406d-b745-e5e773610bda

The ASXL1 gene encodes for Additional Sex Combs Like 1 (ASXL1) protein which is required for chromatin remodeling and ul...
10/16/2025

The ASXL1 gene encodes for Additional Sex Combs Like 1 (ASXL1) protein which is required for chromatin remodeling and ultimately regulates the expression of certain gene activities. Most importantly, it regulates the expression of HOX genes which play a crucial role in fetal development before birth. Mutations of ASXL1 gene are associated with Bohring-Opitz syndrome, myeloid leukemias, myeloproliferative disorders and mastocytosis. Bohring-Opitz syndrome, also known as Oberklaid-Danks syndrome or C-like syndrome is an autosomal dominantly inherited condition characterized by distinctive facial features including exophthalmos, flat nasal bridge and cleft palate, abnormal head size and shape, and posture, growth failure with intellectual disability, seizures, and joint abnormalities. More than 20 mutations in the ASXL1 gene have been identified in this syndrome. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/5e4d4fcd-f750-4ba4-9e3c-7da15a76f995

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) f...
10/15/2025

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) for any given disease by meeting the medical necessity and, thereby improve reimbursement rates. Every order submitted using the Company's CPOE automatically will include the correct ICD10 and CPT codes and will be checked for Medicare LCDs and NCDs to ensure medical necessity is met.

This test detects chromosomal abnormalities in tissue from products of conception (POC) using Fluorescence in situ Hybri...
10/13/2025

This test detects chromosomal abnormalities in tissue from products of conception (POC) using Fluorescence in situ Hybridization (FISH). It helps identify common aneuploidies, including trisomies of chromosomes 13, 18, 21, X, and Y, which are major causes of spontaneous miscarriage and fetal demise. FISH uses fluorescent probes that bind to specific chromosome regions, allowing visualization of abnormal chromosome numbers or structures under a fluorescence microscope. This rapid and reliable method assists in determining whether a pregnancy loss resulted from a genetic abnormality. The results guide genetic counseling, recurrence risk assessment, and future reproductive planning. Testing is particularly useful when conventional karyotyping is unsuccessful due to poor cell growth or tissue degradation. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55be4248-541b-417e-9839-be6d80c320ed

Dermatomyositis is a rare autoimmune disease, affecting approximately 5–10 people per million, most often adults between...
10/11/2025

Dermatomyositis is a rare autoimmune disease, affecting approximately 5–10 people per million, most often adults between 40–60 years and children aged 5–15 years, with a higher prevalence in females. The condition arises from a humoral immune attack on muscle capillaries and arterioles, leading to ongoing microangiopathy. The Anti-Mi-2 antibody test is a highly specific marker for dermatomyositis, although its sensitivity is limited, with only about 25% of patients testing positive. These antibodies are commonly associated with the classic, acute-onset form of dermatomyositis, which presents with characteristic skin manifestations such as the V-neck sign and shawl rash. In affected individuals, muscle enzyme levels are typically abnormal, with elevated creatine kinase, aldolase, AST (aspartate aminotransferase), and LDH (lactate dehydrogenase). Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/5637ceb1-4169-4215-b079-68598656e889

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