
07/25/2025
A meta-analysis published in International Journal of Surgery compared hypothermic oxygenated perfusion (HOPE) vs normothermic machine perfusion (NMP) for extended criteria donor (ECD) livers, HOPE vs dual hypothermic machine perfusion (D-HOPE), and whether to pump back-to-base or initiate at the donor site. 🏥
Some high-certainty evidence findings include:
☑️ HOPE reduced incidence of early allograft disfunction (EAD), major complications, and acute cellular rejection vs. SCS.
☑️ Long-term HOPE (upper 50% percentile of perfusion to preservation time ratio) was associated with lower risk EAD, major complications, non-anastomotic biliary stricture (NAS), and primary non-function (PNF) vs. SCS.
Overall, the authors concluded that in ECD liver transplantation, HOPE is more effective than NMP for preventing EAD, total biliary complications, non-anastomotic biliary strictures, and acute cellular rejection.
Read the full article: www.organ-recovery.com/ex-vivo-hmp-of-ecd-livers/