Life-transforming innovation happens at the convergence of daring science and collaborative culture
07/11/2023
What is the mechanism of action of Brensocatib?
While brensocatib's direct mechanism of action is to reduce active NSPs in circulating neutrophils, the pharmacologic effect in bronchiectasis relies on a reduction of NSP activity in the lung and these reductions were indeed observed in sputum samples.
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