10/06/2025
The SARS-CoV-2 virus is so tiny it would take 1,000 of them lined end-to-end to equal the width of a typical human hair. Still, the string-like genome packs instructions for tricking infected cells into making 27 different proteins.
One of them, called the frameshift element, enables efficient use of the tight viral real estate by letting the same strand make different proteins.
The element is in every variant, which is why it is the target of a potential new antiviral drug from the lab of Matthew Disney, Ph.D., at The Wertheim UF Scripps Institute.
Read more about this fascinating work, the result of a collaboration with Arnab Chatterjee and Sumit Chanda at Scripps Research here: https://wertheim.scripps.ufl.edu/2025/10/06/scientists-blaze-new-path-to-fighting-viral-diseases/
Congratulations to co-first authors Sandra Kovachka, Ph.D., and Amirhossein Taghavi, Ph.D., of The Wertheim UF Scripps Institute, and Jielei Wang, a graduate student in Disney’s lab.
This collaboration was made possible thanks to grants from National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) and Muscular Dystrophy Association