01/05/2026
New Medscape reporting highlights growing concern that high-dose vitamin B6 supplements are linked to peripheral neuropathy, a nerve-damage condition causing numbness, tingling, and burning in the hands and feet — and it’s prompting calls for stricter regulation of B6 products. Neuropathies tied to B6 occur almost exclusively from supplements, not from food, because dietary B6 doesn’t raise levels high enough to cause harm. Scientists note that water-soluble vitamins like B6 were once assumed safe at any dose, but evidence now suggests excess intake from pills can accumulate and injure sensory nerves. Symptoms may worsen with prolonged high doses and can persist even after stopping supplements if nerve damage is advanced. In contrast, deficiencies in certain B vitamins are linked to neuropathy too, especially vitamin B12, which plays a key role in nerve maintenance and myelin sheath health and is commonly used clinically to support neuropathy treatment. Clinical reviews show B12 may help nerve regeneration and reduce nerve pain, particularly when deficiency is present. Healthcare professionals urge consumers to check supplement labels for pyridoxine (vitamin B6) and avoid high doses unless medically indicated. If you notice persistent tingling or weakness, stop the supplement and talk to your clinician about testing nutrient levels.
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Australia will significantly tighten regulation of dietary supplements with vitamin B6 (pyridoxine) starting in 2027, under a reclassification by the Therapeutic Goods Administration. Products with …