03/04/2026
Closing the TNBC Treatment Gap
Triple-negative breast cancer (TNBC) is a large, urgent need: of the ~316,950 U.S. women expected to be diagnosed with invasive breast cancer in 2025, about 10–15% - roughly 32,000–48,000 women - will have TNBC. Outcomes remain poorer than other subtypes: five-year relative survival is ~91% when localized, 66% with regional spread, and 12% when metastatic (77% across all stages), and in the metastatic setting median overall survival is only ~11–13 months with ~11% five-year survival. Even with modern chemo-immunotherapy that improves pathologic complete response and event-free survival in early-stage disease, many patients still relapse. 2216 is our investigational small-molecule lead designed to address this gap by selectively modulating a tumor-survival pathway implicated in TNBC proliferation and treatment resistance; we’re optimizing potency, selectivity, and combination-ready pharmacology to support deep, durable target engagement while maintaining an acceptable safety margin, with ongoing preclinical studies focused on antitumor activity and biomarker-guided patient selection. (2216 is investigational and not approved.)