05/15/2025
“Similar to humans, medications have natural life cycles. They are discovered and researched with the hope of providing effective interventions for the underlying causes and symptoms of specific diseases. Over time, as a medicine’s usage grows, its indications may be expanded, and its safety profile becomes better understood. Eventually, competition from newer medications with equal or better efficacy or fewer adverse events exceeds the comparative risk-benefit ratio of the earlier medication, often decreasing it to the point where it should be retired.”
👩‍⚕️These are not failures, we just have better options now. Very nicely explained in this article: Diphenhydramine: It is time to say a final goodbye
Clark, James H. et al.
World Allergy Organization Journal, Volume 18, Issue 2, 101027