Simple Manna, LLC

03/19/2026

Hypothyroidism slows gut peristalsis and lowers stomach acid, increasing the likelihood of constipation and bacterial overgrowth.

“Your digestion slows down when your metabolic rate slows down from hypothyroidism, and so your stomach becomes sluggish, doesn’t secrete much and doesn’t move fast enough.

People might might eat a carrot today and it might not come out for four or five days.

That’s what happens with hypothyroidism, and speeding up your digestion and secretions, it should be so active streaming fluid from your stomach and pancreas and liver should wash your whole small intestine clean so that no bacteria can thrive in it.” — Ray Peat

“GI symptoms may be ignored in hypothyroidism due to other systemic symptoms of involving cardiovascular, neuromuscular or ophthalmic systems. GI motility is disturbed in hypothyroidism, which can lead to SIBO. SIBO may be responsible for chronic GI symptoms in these patients. It is prudent to evaluate the possibility of SIBO in patients with chronic GI symptoms in hypothyroidism.” — Link between hypothyroidism and small intestinal bacterial overgrowth

03/19/2026

01/03/2026

https://www.facebook.com/share/r/1Brbv1V1L6/

12/12/2025

12/11/2025

11/19/2025

I will be out of the office from **11/23–12/2** to celebrate the holiday with family visiting from out of town. If you anticipate needing any supplements before 11/23, please let me know as soon as possible—response times may be slower while I’m away.

To make ordering easier, I am now on **Fullscript**, where you can conveniently purchase any supplements you may need. I also have a new **Standard Process** website with fast, direct shipping: **simplemanna.standardprocess.com**.

With these options available, I will no longer be shipping items directly after **January 1st**.

Thank you so much for your understanding and have a wonderful Thanksgiving! 🦃

Purchase Standard Process products online from Simple Manna LLC. We are a premier practitioner authorized to sell Standard Process Inc. supplements.

11/17/2025

Understanding toxicity and lethal dose thresholds

This chart ranks substances by their LD50, or the dose required to kill 50% of test animals (usually measured in mg per kilogram of body weight). It provides a standardized comparison of toxicity, showing how vastly potency differs among chemicals that range from essential nutrients to household compounds.

1️⃣ Super toxic compounds
Substances with extremely low LD50 values are lethal in microgram quantities.
🟢 Example: Botulinum toxin has an LD50 of 0.00001 mg/kg, making it the most potent biological toxin known. Just a few nanograms can cause fatal paralysis by blocking acetylcholine release at neuromuscular junctions.

2️⃣ Extremely to very toxic substances
Toxicity rises sharply among compounds that are safe at physiological levels but harmful when overdosed.
🟢 Example: Vitamin D has an LD50 around 10 mg/kg; while essential for calcium balance, excessive intake causes hypercalcemia and kidney damage.
🟢 Example: Caffeine and copper sulfate fall into the “very toxic” range, with lethal doses around 192–481 mg/kg, illustrating that natural origin does not imply safety.

3️⃣ Moderately toxic compounds
Common over-the-counter substances and minerals fall in this range, where toxicity depends on chronic exposure or extreme dosing.
🟢 Example: Acetaminophen (LD50 ≈ 1,944 mg/kg) can cause acute liver failure when overdosed due to depletion of glutathione.
🟢 Example: Sodium chloride (LD50 ≈ 3,000 mg/kg) is essential for fluid balance, yet large acute doses can disrupt osmotic regulation and lead to cardiac arrest.

4️⃣ Slightly to practically non-toxic substances
Compounds with high LD50 values require massive amounts to reach toxic levels.
🟢 Example: Glyphosate and ethanol are classified as slightly toxic, with LD50 values above 5,000 mg/kg, though chronic exposure to ethanol still produces systemic damage.
🟢 Example: Sucrose, with an LD50 around 30,000 mg/kg, is considered practically non-toxic acutely but contributes to metabolic dysfunction with habitual overconsumption.

LD50 values reflect acute toxicity, not long-term health effects. A compound’s danger depends on its dose, exposure duration, route of entry, and individual physiology. Even essential nutrients can become toxic when consumed far beyond the body’s regulatory capacity.

11/15/2025

He's speaking my language 🥰 Butter, butter, and more butter!

11/12/2025

I got my Azure order in with Lifeline Wellness in Knoxville! 🥳 A great way to get organic products.

10/26/2025

So very true!

Every challenge has shaped you into the person you are today.
Stronger. Smarter. Happier. Wiser. 💫

You didn’t just survive; you evolved. 🌻