
09/06/2025
As Parkinson's disease progresses, the brain's response to medications may change. This can lead to symptom fluctuations, known as "on" and "off" periods.
"On" periods are times when the medication is working well, or symptoms are less noticeable. "Off" periods are times when the medication's effects wear off, and symptoms return or worsen. Learn how to manage these fluctuations by visiting: Parkinson.org/library/fact-sheets/managing-off-time