Remy Premier Healthcare Services

01/25/2026

With Andrew Weil, M.D. – I just got recognized as one of their top fans! 🎉

01/25/2026

Winter driving can be unpredictable. Make sure your vehicle is stocked with a driver emergency kit to help you stay prepared on the road. See what to include and get more winter safety tips: bit.ly/4jssgsn

01/25/2026

There's more to winter weather prep than loading up on milk and toilet paper — it's also important to protect yourself, your family and your pets from health and safety risks.

As a large swath of the U.S. braces for a major snow and ice storm, it’s a good time to re-evaluate your preparedness plans. Make sure you have bottled water, batteries and a radio among your emergency supplies, and bundle up to protect yourself from the cold when shoveling. ❄️☃️

Our Get Ready initiative has all these tips and more:
https://vist.ly/4nzxc

01/25/2026

As GLP-1 receptor agonists continue expanding across obesity, diabetes, fatty liver disease, and cardiometabolic care, clinicians are increasingly confronting a pressing question: Does long-term use lead to tolerance, or do apparent “diminishing returns” reflect predictable physiology? It’s a conversation that is evolving quickly as millions of patients move from early weight-loss phases into long-term maintenance. https://t.co/tvpeMUfy4O

01/25/2026

Sleep apnea is a common disorder that can be very serious. In sleep apnea, your breathing stops or gets very shallow while you are sleeping. Each pause typically lasts 10-20 seconds or more. These pauses can occur 20 to 30 times or more an hour. The mos...

01/25/2026

Why Your Health—not Your Wealth—is the Most Important Investment You'll Ever Make

https://robertlufkinmd.substack.com/p/the-ultimate-asset-why-your-healthnot?r=6er0b

01/25/2026

01/25/2026

Every mom deserves a lifetime. Yet cardiovascular disease is the #1 cause of maternal death in the U.S.

That's why we're standing up for moms' hearts on January 23rd in honor of Maternal Health Awareness Day.

Think of the moms packing lunches before sunrise, the friend recovering from childbirth, the coworker balancing meetings and midnight feedings. Their hearts deserve to be protected.

💗 Your gift goes 3X further today to help save lives. Together, let's fight for safer pregnancies and stronger heart care for every family: spr.ly/6008N4ma0

01/25/2026

Prevention doesn’t come in a bottle.

01/25/2026

01/25/2026

01/25/2026

How Exercise Talks to Your Body & Brain 🏋️‍♂️🧠💪

Exercise isn’t just moving muscles...it turns them into endocrine powerhouses that signal your brain, bones, and metabolism. Here’s what really happens:

1. Lactate – the fuel & brain booster

High-intensity lifting or cardio → lactate produced in muscle → circulates → crosses BBB

Fuels neurons and activates BDNF, promoting learning, memory, and plasticity

Brain also makes its own lactate locally, so benefits don’t rely solely on muscle

2. IGF-1 – the growth & repair messenger

Exercise ↑ circulating IGF-1 (mostly liver, partially muscle-mediated)

Crosses BBB → supports neurogenesis, synaptic plasticity, and cognition

In muscle and bone, IGF-1 promotes growth, repair, and bone strength

3. BDNF – the master neurotrophin

Muscle makes BDNF, but mostly local effects (fat oxidation, muscle metabolism)

Exercise-induced brain BDNF rises from neuronal production, triggered by myokines & lactate

Key for neuroplasticity and brain health

4. Irisin & Cathepsin B – messengers from muscle

Released during exercise → circulate → trigger brain BDNF gene expression

Also help convert white fat to brown fat, enhancing fat burning

5. IL-6 – the regulated inflammatory signal

Pulsatile IL-6 from muscle → anti-inflammatory signaling

Supports insulin sensitivity, metabolism, and brain plasticity

Not the same as chronic inflammation

6. Bone & musculoskeletal health

Resistance exercise and weight-bearing activity stimulate:
Bone remodeling via mechanical stress and IGF-1
Muscle hypertrophy & repair
Protection against sarcopenia (muscle aging) and frailty

7. Metabolism & fat burning

Muscle contraction + myokines → ↑ lipid oxidation

Irisin, lactate, and AMPK signaling → convert fat for fuel

Exercise improves insulin sensitivity and lipid profiles, lowering diabetes and cardiovascular risk

8. Putting it all together

Exercise triggers a network of signals:

Muscle → myokines & metabolites

Circulation → brain, fat, bone

Brain → BDNF, plasticity, neuroprotection

Metabolism → fat burning, glucose control

Bones & muscles → strength, repair, aging resilience

💡Takeaway: Exercise is a full-body communication system. Muscles don’t just move...they talk to your brain, bones, fat, and metabolism to keep you sharper, stronger, and healthier as you age.

If you want to learn more about the benefits of exercise check out my book WIN amzn.to/3yZgRcq

If you want to stay updated on the health information I put out subscribe to my health newsletter drjamesdinic.com and my Substack
https://substack.com/