12/11/2025
When depression does not improve with standard medications and therapy, it is called treatment resistant depression. This can feel incredibly discouraging for patients and families. Esketamine (Spravato) therapy offers another option by working on a different neurotransmitter system in the brain.
At Heal + Glow Wellness, esketamine (Spravato) is considered for carefully selected adults after a thorough mental health evaluation. It acts on glutamate pathways, which are involved in learning, memory, and mood regulation. Many patients experience a rapid lift in mood and thought patterns within hours to days, which is very different from traditional antidepressants that may take weeks to show benefit.
Treatments are provided in a controlled clinical setting with monitoring before, during, and after each session. Esketamine (Spravato) is used as part of a comprehensive care plan that includes ongoing therapy and follow up visits so gains are integrated into daily life rather than treated as a short term fix.
To learn more about whether esketamine (Spravato) treatment may be appropriate, visit healandglowwellness.com and schedule a consultation.