12/12/2025
From: The Medical Letter, December 8/2025 issue. An unbiased and truly researched source for drugs and therapeutics. They reviewed 40 large studies to provide the below information!
"Acetaminophen has been the drug of choice for treatment of fever and during pregnancy for decades.
The US Department of Health and Human Services has issued an announcement expressing concern about a potential link between acetaminophen exposure in utero and neurodevelopmental disorders such as autism.
Data from observational studies have been conflicting, but higher-quality studies have been less likely to show an association between maternal acetaminophen use and neurodevelopmental disorders in their offspring.
Fever during pregnancy has itself been associated with adverse neurodevelopmental outcomes, and it can cause neural tube defects during the first trimester.
Alternative drugs for treatment of fever or pain (e.g., NSAIDs, opiods) have been associated with significant toxicity when used during pregnancy.
Major professional organizations continue to recommend acetaminophen for first-line treatment of fever and pain during pregnancy."
"...available evidence is insufficient to definitively link in utero acetaminophen exposure and autism and ADHD in childhood."