11/20/2025
Lifting weights releases myokines which are signaling proteins produced by muscle cells, which have beneficial effects on inflammation, hormone levels, blood sugar levels, brain health and so much more.
Myokines act as messengers, communicating between muscles and other organs, impacting various bodily functions.
Myokines are released during muscle contractions when weight training and play a crucial role in mediating the positive effects of exercise.
Myokines, particularly IL-6, have been shown to reduce inflammation, both acute and chronic low-grade inflammation, associated with inactivity, aging or metabolic disorders.
Additionally, myokines, including IL-6 and irisin, can improve glucose uptake, enhance insulin sensitivity and regulate glucose metabolism in the liver and pancreas.
Some myokines, like FGF21, can cross the blood-brain barrier and have been shown to improve cognitive function, reduce inflammation and protect against neurodegenerative diseases.
Strength training regulates hormones by boosting beneficial anabolic hormones like testosterone and growth hormone, increasing insulin sensitivity to control blood sugar, and reducing catabolic stress hormones like cortisol. It helps maintain a healthy balance of hormones, which can improve mood, muscle mass, bone density, and metabolism, particularly as people age.
PMID: 15831061, 20827340
