UK Sanders-Brown Center on Aging

UK Sanders-Brown Center on Aging The mission of the SBCoA is to enable healthy brain aging for all. The Center is directed by Linda J. Van Eldik, PhD, Professor, Department of Neuroscience.

The Sanders-Brown Center on Aging (SBCoA) was established in 1979, and received funding as one of the original ten National Institutes of Health Alzheimer's Disease Centers. Internationally acclaimed, the SBCoA is recognized for its contributions to the fight against brain diseases that are associated with aging. The SBCoA has more than 100 faculty and staff pursuing basic and clinical research in Alzheimer's disease and related neurodegenerative disorders, stroke, prion disease, and normal brain aging. The Center is a global pioneer in Alzheimer's disease research, with over thirty years of published work and 700 volunteers, some with the disease and some without, who are studied over time and donate their brains when they die. The cutting-edge research focuses on identifying problems as early as possible, before memory loss develops, so that Alzheimer's disease can be prevented or delayed. The ultimate goal of the Center on Aging is to catalyze innovative and outstanding brain research while ensuring a more rapid rate of progress toward new therapies to delay or prevent age-related brain diseases like Alzheimer's disease, so that our human volunteers, patients, and caregivers become the beneficiaries of our advances in knowledge.

In the early stages of dementia and need support? The ๐„๐š๐ซ๐ฅ๐ฒ ๐’๐ญ๐š๐ ๐ž ๐’๐ฎ๐ฉ๐ฉ๐จ๐ซ๐ญ ๐†๐ซ๐จ๐ฎ๐ฉ provides a place to be with others who m...
09/04/2025

In the early stages of dementia and need support? The ๐„๐š๐ซ๐ฅ๐ฒ ๐’๐ญ๐š๐ ๐ž ๐’๐ฎ๐ฉ๐ฉ๐จ๐ซ๐ญ ๐†๐ซ๐จ๐ฎ๐ฉ provides a place to be with others who may be traveling a similar journey! Call for details!
UK College of Medicine The Alzheimer's Association - Greater Kentucky and Southern Indiana Chapter Fayette County Cooperative Extension Family & Consumer Sciences Dementia Friendly Lexington

Dr. Linda Van Eldik and Dr. Lauren Whitehurst are sharing about healthy brain aging and resources at Pralltown Day! We h...
08/30/2025

Dr. Linda Van Eldik and Dr. Lauren Whitehurst are sharing about healthy brain aging and resources at Pralltown Day! We hope youโ€™ll stop by and see us!

Kudos to ๐Œ๐š๐œ๐š๐ฎ๐ฅ๐ž๐ฒ ๐‹๐š๐› scientists Nick Constantino, Riley Irmen, Clair Ashley, and Sierra Turner for sharing  their resea...
08/29/2025

Kudos to ๐Œ๐š๐œ๐š๐ฎ๐ฅ๐ž๐ฒ ๐‹๐š๐› scientists Nick Constantino, Riley Irmen, Clair Ashley, and Sierra Turner for sharing their research findings at the meeting last week!

GABAergic dysfunction underlies tau-dependent sleep loss but is rescued by targeting beta activity with zolpidem.

Severity of sleep loss does not correlate with Aฮฒ plaque load.

Connecting Lactate Metabolism in Reactive Microglia to Early Alzheimer's Disease.

International Society for Neurochemistry UK College of Medicine

Last week several researchers from the ๐“๐ก๐ข๐›๐š๐ฎ๐ฅ๐ญ ๐‹๐š๐› presented during the   meeting in New York!  Posters presented inclu...
08/28/2025

Last week several researchers from the ๐“๐ก๐ข๐›๐š๐ฎ๐ฅ๐ญ ๐‹๐š๐› presented during the meeting in New York! Posters presented included:

Deciphering the Role of Astrocytic Insulin Receptor Overexpression on Vascular Dynamics and Gait in an Amyloidosis Model
Validation of Proteins Involved in the Insulin Receptor Beta Subunit Pathway from Astrocyte Enriched Brain Samples of Overexpressed Insulin Mice
2-photon imaging of astrocyte metabolic activity in an awake mouse using the PercevalHR and Peredox nanosensors.

The Thibault Lab primarily studies the effect of aging on astrocytic calcium dysregulation in a mouse model of amyloidosis (5xFAD). New projects currently under development include investigating the impact of overexpressing and knocking out insulin receptors in astrocytes and using metabolic nanosensors to assess astro- and neurovascular coupling in young and aged mice. To find out more about the work of the Thibault Lab, visit https://www.uky.edu/~othibau/index.shtml.
International Society for Neurochemistry UK College of Medicine

Our very own ๐ƒ๐ซ. ๐„๐ฅ๐ข๐ณ๐š๐›๐ž๐ญ๐ก ๐‘๐ก๐จ๐๐ฎ๐ฌ shares how meaningful activities are what changes and nourishes the brain from a neuro...
08/27/2025

Our very own ๐ƒ๐ซ. ๐„๐ฅ๐ข๐ณ๐š๐›๐ž๐ญ๐ก ๐‘๐ก๐จ๐๐ฎ๐ฌ shares how meaningful activities are what changes and nourishes the brain from a neuroplasticity standpoint!
Engaged Aging Lab University of Kentucky Research UK College of Medicine

Host Renee Shaw examines the reasons why older workers are choosing to stay in the workforce longer or re-entering after retirement. Experts provide advice on the resources and programs available to assist seniors in finding or retaining employment, as well as discussing the advantages of an interge...

We were delighted to share at the Aging Life Care Association Midwest Chapter Conference  last week! ๐ƒ๐ซ. ๐๐ข๐ง๐š๐ซ ๐‚๐จ๐ฌ๐ค๐ฎ๐ง & ...
08/25/2025

We were delighted to share at the Aging Life Care Association Midwest Chapter Conference last week! ๐ƒ๐ซ. ๐๐ข๐ง๐š๐ซ ๐‚๐จ๐ฌ๐ค๐ฎ๐ง & ๐ƒ๐ซ. ๐„๐ฅ๐ข๐ณ๐š๐›๐ž๐ญ๐ก ๐‘๐ก๐จ๐๐ฎ๐ฌ shared about available treatments including anti-amyloid therapies and sensory-based approaches! There are things we ๐‚๐€๐ ๐ƒ๐Ž to improve the lives of persons with Alzheimer's disease!
UK Kentucky Neuroscience Institute Engaged Aging Lab

Art can help keep the brain healthy and engaged! Grab your paintbrush and enjoy this watercolor tutorial by one of our v...
08/23/2025

Art can help keep the brain healthy and engaged! Grab your paintbrush and enjoy this watercolor tutorial by one of our very talented Clinical Research Associates!
UK College of Medicine Age-Friendly Lexington

Painting: Watercolor SunsetA follow-along tutorial on how to paint this beautiful sunset in watercolors.Presenter: Tonya HurstSpecial Thanks to the Kentucky ...

The University of Kentucky Center of Excellence in Rural Health will host the 10th Annual Kentucky Rural Telehealth Summ...
08/22/2025

The University of Kentucky Center of Excellence in Rural Health will host the 10th Annual Kentucky Rural Telehealth Summit on Sept. 25 at the Administrative Office of the Courts in Frankfort, Ky.

Learn more and register ๐Ÿ‘‡

The University of Kentucky Center of Excellence in Rural Health (UK CERH) will host the 10th Annual Kentucky Rural Telehealth Summit on Sept. 25 in Frankfort, Ky.

At the foundation of UKโ€™s Neuroscience Research Priority Area (NRPA) is the belief that an environment that allows for d...
08/22/2025

At the foundation of UKโ€™s Neuroscience Research Priority Area (NRPA) is the belief that an environment that allows for dedicated research time and fosters teamwork also enhances problem-solving, accelerates learning, promotes creativity and builds stronger relationships, said ๐‹๐ข๐ง๐๐š ๐•๐š๐ง ๐„๐ฅ๐๐ข๐ค, ๐๐ก๐ƒ, ๐๐‘๐๐€, co-director, co-director of KNI and director of the UK Sanders-Brown Center on Aging.
UK College of Medicine University of Kentucky Research

Kentucky Neuroscience Institute Research team is working together across campus to turn scientific discoveries into real treatments that improve brain health and help patients in Kentucky and beyond.

This week we presented about navigating care in the final stages of dementia and caregiving through the lens of sensatio...
08/22/2025

This week we presented about navigating care in the final stages of dementia and caregiving through the lens of sensation in dementia care during the KY Association of Hospice & Palliative Care. Takeaways:

When a person with dementia becomes agitated, behavioral, environmental, and non-pharmacological approaches should always be tried first.

Almost all of our efforts are palliative by nature as we cannot prevent the progression of any form of dementia.

Lessening the burden of care for caregivers should be a goal of care!

Carers can enrich the environment to provide comfort and support for those living with dementia.

The LiBBY Study is testing THC and CBD in persons who have dementia and experience agitation. We are currently enrolling!

Engaged Aging Lab

The UK College of Dentistry recently hosted more than 400 orthodontic residents from across the U.S. and Canada for the ...
08/22/2025

The UK College of Dentistry recently hosted more than 400 orthodontic residents from across the U.S. and Canada for the 36th annual Graduate Orthodontic Residents Program.

"Itโ€™s a great feeling to be able to show off our campus and the Lexington area.โ€

The University of Kentucky College of Dentistry hosted over 400 orthodontic residents from across the U.S. and Canada for the 36th annual Graduate Orthodontic Residents Program (GORP).

Learn more about the ๐’๐ญ๐š๐ญ๐ž ๐‡๐ž๐š๐ฅ๐ญ๐ก ๐ˆ๐ง๐ฌ๐ฎ๐ซ๐š๐ง๐œ๐ž ๐๐ซ๐จ๐ ๐ซ๐š๐ฆ (๐’๐‡๐ˆ๐) at the next Virtual Dementia program. Connect with experts an...
08/21/2025

Learn more about the ๐’๐ญ๐š๐ญ๐ž ๐‡๐ž๐š๐ฅ๐ญ๐ก ๐ˆ๐ง๐ฌ๐ฎ๐ซ๐š๐ง๐œ๐ž ๐๐ซ๐จ๐ ๐ซ๐š๐ฆ (๐’๐‡๐ˆ๐) at the next Virtual Dementia program. Connect with experts and get your questions answered! Register at https://bit.ly/SHIPsession.
UK College of Medicine Age-Friendly Lexington

At the foundation of UKโ€™s Neuroscience Research Priority Area is the belief that an environment that promotes dedicated ...
08/21/2025

At the foundation of UKโ€™s Neuroscience Research Priority Area is the belief that an environment that promotes dedicated research and teamwork enhances problem-solving, accelerates learning, promotes creativity and builds stronger relationships.

Kentucky Neuroscience Institute Research team is working together across campus to turn scientific discoveries into real treatments that improve brain health and help patients in Kentucky and beyond.

Sanders-Brown's ๐ƒ๐ซ. ๐‰๐จ๐ซ๐๐š๐ง ๐‡๐š๐ซ๐ฉ is working to answer questions about stroke and cognitive recovery!
08/21/2025

Sanders-Brown's ๐ƒ๐ซ. ๐‰๐จ๐ซ๐๐š๐ง ๐‡๐š๐ซ๐ฉ is working to answer questions about stroke and cognitive recovery!

UK researchers are studying stroke-related brain changes to better predict who is at risk for dementia and aim to improve recovery, especially for patients in rural and Appalachian areas.

Up to one-third of stroke survivors go on to develop dementia and cognitive impairment. But is it possible to predict, a...
08/21/2025

Up to one-third of stroke survivors go on to develop dementia and cognitive impairment. But is it possible to predict, at the time of a stroke, who will have the best cognitive recovery?

Thatโ€™s a question neuropsychologist Dr. Jordan Harp hopes to answer.

UK researchers are studying stroke-related brain changes to better predict who is at risk for dementia and aim to improve recovery, especially for patients in rural and Appalachian areas.

UK HealthCare has implemented a powerful new tool in the ongoing effort to save lives through organ donation: a seamless...
08/21/2025

UK HealthCare has implemented a powerful new tool in the ongoing effort to save lives through organ donation: a seamless registration feature within the MyChart patient portal.

Learn more, including how to easily navigate the registration process in MyChart ๐Ÿ‘‡

UK HealthCare UK HealthCare launches new organ donation sign-up through MyChart By Jared Holt Wednesday Video provided by UK HealthCare Corporate Communications LEXINGTON, Ky. (Aug. 20, 2025) โ€” UK HealthCare has implemented a powerful new tool in the ongoing effort to save lives through organ dona...

08/20/2025

UK HealthCare was designated as a Magnet organization in 2016 and 2021 by the ANCC Magnet Recognition Programยฎ and we are now applying for redesignation. We invite patients, family members, staff, and other interested parties to provide feedback via email or direct mail by Sept. 19, 2025.

Read our official public notice announcement with full details.

On this episode of โ€œBehind the Blue,โ€ Dr. Larry Goldstein talks about the origins of the Department of Neurology in the ...
08/20/2025

On this episode of โ€œBehind the Blue,โ€ Dr. Larry Goldstein talks about the origins of the Department of Neurology in the UK College of Medicine and its evolution into a leader in patient care, education and research.

UK HealthCare โ€˜Behind the Blueโ€™: Larry Goldstein on 60 years of neurology at UK By Kody Kiser and Rick Childress Monday LEXINGTON, Ky. (August 18, 2025) โ€“ The University of Kentucky College of Medicineโ€™s Department of Neurology is marking its 60th anniversary, celebrating a legacy that began...

Dr. Brooke Hudspeth, UK College of Pharmacy Chief Practice Officer, shares what you should know about two common new wei...
08/19/2025

Dr. Brooke Hudspeth, UK College of Pharmacy Chief Practice Officer, shares what you should know about two common new weight-loss drugs.

Youโ€™ve likely heard about glucagon-like peptide-1 agonists โ€” commonly referred to as GLP-1 medications, and more widely recognized through pharmaceutical brand names like Ozempic and Mounjaro.

Our robust and growing epilepsy program has become known for its innovative approach to successful patient assessments. ...
08/19/2025

Our robust and growing epilepsy program has become known for its innovative approach to successful patient assessments. It is the goal of the epilepsy team, the Kentucky Neuroscience Institute and the UK HealthCare Comprehensive Epilepsy Program to bridge the treatment gap.

UKโ€™s epilepsy team is using advanced imaging and teamwork to better pinpoint where seizures start in the brain, helping more patients find effective treatments and improve their quality of life.

Neurologist Dr. Sharoon Qaiser goes beyond the typical history and physical exam for young patients. The director of UK ...
08/18/2025

Neurologist Dr. Sharoon Qaiser goes beyond the typical history and physical exam for young patients. The director of UK HealthCareโ€™s Children and Young Adult Headache & Research Program asks patients to draw pictures that reflect their headaches and pain.

The Children and Young Adult Headache Research Program is using innovative tools like AI, patient drawings, and new medications to improve diagnosis and treatment for children suffering from migraines, especially in underserved areas.

08/18/2025

Meet Brad Tannen, our new chair of ophthalmology and visual sciences!

Lisa Buede is among the first patients at UK Markey Cancer Center to benefit from a new treatment approach that uses adv...
08/15/2025

Lisa Buede is among the first patients at UK Markey Cancer Center to benefit from a new treatment approach that uses advanced surgical robots to diagnose and treat early stage lung cancer in one session.

โ€œWeโ€™re now able to take patients from โ€˜you might have cancerโ€™ to โ€˜your cancer is goneโ€™ in a single day.โ€

By the time 59-year-old Lisa Buede learned she had stage 1 lung cancer, the tumor was already gone. The UK Markey Cancer Centerโ€™s new same-day procedure combines diagnosis and treatment for early stage lung cancers using advanced surgical robots, eliminating weeks of waiting between biopsy and sur...

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