09/19/2025
We have started recommending an iodine swab to clean each nostril. This is important as a daily routine.
💨 Everyday nasal spray shows surprising power against COVID—and more
A simple over-the-counter nasal spray, already used worldwide for allergies, may also protect against COVID-19.
In a phase 2 clinical trial led by Saarland University, Germany, researchers tested azelastine, a medication available in more than 70 countries. Over eight weeks, only 2.2% of people using the spray contracted COVID-19—compared to 6.7% in the placebo group. That’s a two-thirds reduction in cases.
Even more intriguing, azelastine also appeared to reduce symptomatic infections, respiratory illnesses, and even rhinoviruses (the common cold), hinting at broader antiviral effects. Scientists think the spray works by blocking viral replication directly in the nose and upper airways—the entry point for most respiratory pathogens.
Because it’s already approved for hay fever and allergies, azelastine could become an accessible, low-cost preventive option. While it’s not yet authorized as a COVID treatment, researchers say it may be especially useful for vulnerable individuals and during seasonal surges of respiratory infections. Larger, multicenter studies are now needed to confirm these results.
đź“– Source:
Lehr T, Meiser P, Selzer D, et al. Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial. JAMA Internal Medicine, September 2, 2025.