The Journal of Urology

The Journal of Urology The official journal of the AUA, The Journal of Urology® is the most widely read and highly cited p

In this article, researchers explore why some patients become resistant to BCG, the gold‑standard treatment for high‑ris...
02/27/2026

In this article, researchers explore why some patients become resistant to BCG, the gold‑standard treatment for high‑risk non–muscle‑invasive bladder cancer, and how emerging combination therapies may boost effectiveness, reduce side effects, and preserve the bladder. The review highlights promising chemo‑ and immunotherapy pairings, the lingering impact of BCG shortages, and the need for long‑term trials to guide safer, more durable treatment options.

🔗 Click to read more: https://bit.ly/4rFFWUa

02/27/2026

HEAR FROM THE AUTHOR! Thank you Dr. Wayne Kuang from Man vs. Prostate for talking about your article, "BladderSpan: Years Lived With Optimal Detrusor Function" from the February issue of JU!

Click to read the article: https://bit.ly/3N5d5cY

Upper tract urothelial carcinoma (UTUC) requires better diagnostic methods than current invasive procedures or low-sensi...
02/09/2026

Upper tract urothelial carcinoma (UTUC) requires better diagnostic methods than current invasive procedures or low-sensitivity urine cytology, prompting the need for a reliable noninvasive biomarker. Oncuria-Detect, a multiplex urine assay, demonstrated superior sensitivity and negative predictive value compared to voided urine cytology for noninvasive (90% vs. 58% sensitivity and 92% vs. 66% NPV) and low-grade tumors (94% vs. 40% sensitivity and 97% vs. 69% NPV), suggesting it could potentially reduce reliance on invasive diagnostics.

🔗 Click to read more: https://bit.ly/3NkmLAc

In this comment, the authors note that patients with a prior transecting urethroplasty face roughly double the risk of A...
02/05/2026

In this comment, the authors note that patients with a prior transecting urethroplasty face roughly double the risk of AUS complications, underscoring the importance of preserving urethral blood supply when future incontinence treatment is likely.

🔗 Click to read more: https://bit.ly/4qugX5K

Insertion of an artificial urinary sphincter (AUS) following urethroplasty presents challenges, with outcomes varying ba...
02/02/2026

Insertion of an artificial urinary sphincter (AUS) following urethroplasty presents challenges, with outcomes varying based on the surgical technique; it was found that nontransecting urethroplasty resulted in explantation-free survival rates of 69% at 5 years and 62% at 10 years compared to transecting urethroplasty, which had rates of 38% and 17%, respectively. Transecting urethroplasty is linked to higher AUS complication rates, evidenced by a 56.2% occurrence of complications requiring explantation due to infection, erosion, or mechanical failure.

🔗 Click to read more: https://bit.ly/4qugX5K

The Artificial Urinary Sphincter Clinical Outcomes trial demonstrated a significant improvement in male stress urinary i...
01/29/2026

The Artificial Urinary Sphincter Clinical Outcomes trial demonstrated a significant improvement in male stress urinary incontinence, with 94% of participants achieving a ≥50% reduction in pad weight and 60% achieving zero pad use at 12 months post-activation. Additionally, 92% of participants were satisfied with the device, indicating a substantial enhancement in quality of life, while only 15% experienced serious adverse events, reflecting an acceptable safety profile.

🔗 Click to read more: https://bit.ly/4jDEoqw

This study aimed to assess if febrile urinary tract infection (fUTI) risk could be anticipated in children with vesicour...
01/26/2026

This study aimed to assess if febrile urinary tract infection (fUTI) risk could be anticipated in children with vesicoureteral reflux (VUR) upon stopping continuous antibiotic prophylaxis (CAP) without the invasive procedure of voiding cystourethrogram (VCUG), with findings showing that 11% of the 386 children experienced a fUTI post-CAP cessation. The study's predictive model revealed that bowel and bladder dysfunction, as well as high-grade VUR, were significant risk factors for fUTI, with a concordance index (C index) of 0.7 enhancing the model's moderate predictive capabilities.

🔗 Click to read more: https://bit.ly/45a9vEq

Shared decision-making is critical for patients with localized prostate cancer, but this study highlights the variable n...
01/21/2026

Shared decision-making is critical for patients with localized prostate cancer, but this study highlights the variable nature of patient participation, with a median of 19.9% speaking time during consultations and only 3.4% of speech related to decision-making processes. Efforts to elicit patient values actively are essential, as higher tumor risk was associated with greater involvement, but no other demographic or clinical predictors emerged.

🔗 Click to read more: https://bit.ly/45hnFDI

In this comment, the authors highlight new findings linking time spent outdoors with higher testosterone levels—while al...
01/19/2026

In this comment, the authors highlight new findings linking time spent outdoors with higher testosterone levels—while also noting that the relationship may be bidirectional. The takeaway? Regardless of cause and effect, getting outside is tied to healthier behaviors and better long-term wellness.

🔗 Click to read more: https://bit.ly/49X5Ps8

Testosterone is a critical hormone that impacts various aspects of men's health, and understanding its association with ...
01/16/2026

Testosterone is a critical hormone that impacts various aspects of men's health, and understanding its association with lifestyle factors such as time spent outdoors (TSO) is crucial, especially given increasingly sedentary lifestyles. Analysis of 2205 men revealed that increased TSO is significantly associated with higher serum testosterone levels (b = 9.25 per 1 hour outside daily, P = .007), and a 14% decrease in the odds of low testosterone (odds ratio 0.86, P = .01), independent of several confounding variables.

🔗 Click to read more: https://bit.ly/3LHmPJA

This study explored the potential of micro-ultrasound-guided biopsy (MB) as a resource-effective alternative to MRI/ultr...
01/15/2026

This study explored the potential of micro-ultrasound-guided biopsy (MB) as a resource-effective alternative to MRI/ultrasound fusion-guided biopsy (PFB) for detecting clinically significant prostate cancer (csPCa). The results showed that MB detected csPCa at higher rates in combined (45% vs. 34%) and systematic biopsies (39% vs. 24%) compared to PFB.

🔗 Click to read more: https://bit.ly/3YGLiBS

In this study, researchers used imaging mass cytometry and machine learning to map the immune microenvironment of Hunner...
01/09/2026

In this study, researchers used imaging mass cytometry and machine learning to map the immune microenvironment of Hunner lesions in IC/BPS. Findings reveal macrophage-rich neighborhoods and distinct immune cell patterns, offering clues to disease mechanisms and future therapies.

🔗 Read more: https://bit.ly/4j7u4qP

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