Every Cure

04/24/2026

Can Every Cure prioritize one disease over another and accelerate a cure on demand? It’s one of the most common questions we get.

The reality is that Every Cure is built to look across all 18,000 diseases at once, systematically scoring thousands of drugs against each one. We are not yet in a position to focus exclusively on a single condition by request. Instead, we work through this massive landscape methodically, reviewing more than 1,000 opportunities every month to identify the most promising matches between existing drugs and diseases.

What is powerful is the scale of this approach. There is a real chance we are already evaluating a potential treatment for the disease you care about.

In many cases, the answer is not starting from scratch. It is uncovering something that may already exist and accelerating it forward with the right data, resources, and collaboration.

This clip was recorded at the Peter Diamandis Abundance Summit. So grateful to be part of a community pushing the boundaries of what’s possible in healthcare and beyond.

04/15/2026

03/03/2026

While battling for my life in the ICU, a seemingly minor symptom caught my attention amidst the life-threatening failure of my vital organs.

Small bumps, known as blood moles, emerged on my chest and shoulders during my relapses.

This observation became a critical piece of my medical puzzle, hinting at a deeper issue related to the VEGF and mTOR pathways.

While experimenting on my own tissue I found that my mTOR pathway was turned into overdrive and I began taking Sirolimus, an mTOR inhibitor never administered for Cattleman Disease before.

A couple days later I began feeling better and my blood moles started shrinking away!

Leveraging existing medications for new applications can lead to rapid, effective, and often less costly solutions, especially for rare and complex diseases like mine.

Now, nearly a decade into remission, I celebrate not just my survival but the strategy that made it possible.

As Cure continues to explore the vast potential of existing drugs, we want to hear from you!

What other life-saving discoveries lie within our current pharmacopeia, waiting to be uncovered through the power of repurposing?

01/23/2026

01/08/2026

We are proud to announce that Every Cure is launching a new drug repurposing program focused on DFMO for Bachmann–Bupp Syndrome, an ultra-rare genetic condition that has been identified in only about 20 children worldwide.

Children with Bachmann–Bupp Syndrome often require feeding tubes, have limited motor control, and face significant daily challenges. The condition was first described by Dr. Bachmann and Dr. Bupp, who also pioneered the use of DFMO—a drug originally developed to treat African sleeping sickness—to target the underlying biology of this disease. In treated patients, DFMO has shown the potential to reverse key symptoms, including removing feeding tubes and helping children sit up and interact more fully with their families.

So far, approximately six children have been treated with DFMO, with meaningful improvement observed in five of them. This is exactly the kind of condition that is often overlooked because of its rarity and exactly why drug repurposing matters.

We are deeply grateful to Drs. Bachmann and Bupp for their groundbreaking work, and we are honored to partner with them to identify more patients, expand access to treatment, and help unlock better outcomes for children and families living with this devastating condition.

Click the link below to read the full press release!
https://newsroom.corewellhealth.org/news-releases?item=125205

12/31/2025

Today we’re excited to reveal 2025 Every Cure Discovery Wrapped!

This year, our AI reviewed 39,284,922 potential drug–disease matches — and our team of scientists rolled up their sleeves to manually evaluate 9,302 of the most promising ones. Together, we explored nearly 88 million data points across our biomedical knowledge graphs, spanning 9.23M nodes and 77.17M edges, all with one goal: finding cures hiding in plain sight.

We collaborated with incredible partners across academia, industry, and tech — and yes, we even shipped code to production with zero bugs.

Here’s to 2026, and to every patient still waiting.

12/03/2025

The lesson of this video is that if you have a rare disease, you need to go to the most experienced centers because in my case even the bus driver could tell I was a Castleman Disease patient when top doctors at other hospitals couldn’t!

12/02/2025

In 2024, Joseph was told he had two choices: die in the hospital or die at home.

Instead, a combination of 3 repurposed drugs identified by our team saved his life.

Every Cure is a nonprofit, and the only way we can continue discovering and delivering these lifesaving repurposed treatments is through your support.

His story is powerful, but it represents something far bigger: there are millions of patients just like Joseph who still don’t have a cure, even though the medicines that could help them may already exist.

On this Giving Tuesday, I hope you’ll go to EveryCure.org/donate as it directly fuels the work that gives patients like Joseph another chance.

11/27/2025

Just days after I arrived at Georgetown, my dad called to tell me my mom had brain cancer.

I rushed home, and within 48 hours she was in a 4.5-hour awake brain surgery — the kind where they open your skull and wake you up mid-procedure so they don’t remove too much and affect your ability to speak.

My sisters, my dad, and I were terrified, just waiting for word that she made it through.

When we finally walked into her room, her head wrapped and a drain bulb beside her, she looked right at us, pointed to her bandage, and said, “Chiquita banana lady.”

After everything she had just endured, her first instinct was to make us laugh.

That moment said everything about who she was — strength, humor, and love all wrapped together.

11/26/2025