
09/20/2025
Low T, But Why? Cracking the Code of Primary vs. Secondary Hypogonadism
Testosterone isn’t just about muscles and s*x drive—it’s a hormone that fuels energy, motivation, metabolism, and overall vitality. When levels drop, life feels… flat. But before reaching for a quick fix, it’s important to understand why testosterone might be low. That’s where the distinction between primary and secondary hypogonadism comes in.
Primary Hypogonadism: The Te**es Can’t Keep Up
In primary hypogonadism, the issue lies in the te**es themselves. Despite the brain sending out the hormonal “signals” to make testosterone, the te**es can’t respond effectively. Common causes include:
Genetic conditions (like Klinefelter syndrome)
Injury or surgery affecting the te**es
Certain chemotherapy or radiation treatments
Age-related testicular decline
In this scenario, the command center (the brain) is doing its job, but the factory (the te**es) is malfunctioning. Blood tests usually reveal high levels of LH and FSH (the brain’s messengers), but low testosterone because the signal isn’t being carried out.
Secondary Hypogonadism: A Brain-Signal Problem
Secondary hypogonadism, on the other hand, means the te**es could produce testosterone, but the brain isn’t sending the right signals. The hypothalamus and pituitary—tiny glands with massive influence—are at the heart of this problem. Causes often include:
Pituitary tumors
Head injuries
Chronic illnesses
Certain medications (like opioids or steroids)
Extreme stress or obesity
Chronic cannabis use
In this case, bloodwork typically shows low LH and FSH, paired with low testosterone—because the command center itself is off.
Read the blog and subscribe to our email list..
https://axioshealthco.com/low-t-but-why-cracking-the-code-of-primary-vs-secondary-hypogonadism/
Listen to the podcast
https://youtu.be/bNA89fycpro?feature=shared
www.axioshealthco.com
720-899-9400